Lipase inhibitors

A compound of formula (I)

• wherein:
• L1 is a bond, C1-10 alkylene, C2-10 alkenylene, or C2-10 alkynylene, wherein said alkylene, said alkenylene or said alkynylene is optionally substituted with one or more groups independently selected from —C1-4 alkyl, —CF3, —CN, —OH, —O(C1-4 alkyl), —NH2, —NH(C1-4 alkyl), or —N(C1-4 alkyl)(C1-4 alkyl), and further wherein one or more —CH2— units comprised in said alkylene, said alkenylene or said alkynylene are each optionally replaced by a group independently selected from —O—, —NH—, —N(C1-4 alkyl)-, —CO—, —CO—NH—, —NH—CO—, —S—, —SO—, or —SO2—;
• R1 is independently selected from C1-4 alkyl, halogen, —CF3, —CN, —OH, —O(C1-4 alkyl), —NH2, —NH(C1-4 alkyl), or —N(C1-4 alkyl)(C1-4 alkyl), a 5 to 7-membered, saturated or unsaturated carbon ring structure wherein optionally one to three of the carbon atoms are replaced by N, O, or S, said ring structure being optionally substituted with C1-4 alkyl, halogen, —CF3, —CN, —OH, —O(C1-4 alkyl), —NH2, —NH(C1-4 alkyl), or —N(C1-4 alkyl)(C1-4 alkyl), or a aryl or heteroaryl optionally substituted with C1-4 alkyl, halogen, —CF3, —CN, —OH, —O(C1-4 alkyl), —NH2, —NH(C1-4 alkyl), or —N(C1-4 alkyl)(C1-4 alkyl);
• R2 is optionally substituted aryl or optionally substituted heteroaryl but not pyrazolyl, wherein said aryl or said heteroaryl may be substituted with one or more groups independently selected from C1-4 alkyl, halogen, —CF3, —CN, —OH, —O(C1-4 alkyl), —NH2, —NH(C1-4 alkyl), or —N(C1-4 alkyl)(C1-4 alkyl);
• or R2 is pyrazolyl optionally substituted with one or more groups independently selected from C1-4 alkyl, halogen, —CF3, —CN, —O(C1-4 alkyl), —NH2, —NH(C1-4 alkyl), or —N(C1-4 alkyl)(C1-4 alkyl)
• R3 is C1-10 alkylene, C2-10 alkenylene, or C2-10 alkynylene, wherein said alkylene, said alkenylene or said alkynylene is optionally substituted with one or more groups independently selected from halogen, —CF3, —CN, —OH, —O(C1-4 alkyl), —NH2, —NH(C1-4 alkyl), or —N(C1-4 alkyl)(C1-4 alkyl), and further wherein one or more —CH2— units comprised in said alkylene, said alkenylene or said alkynylene are each optionally replaced by a group independently selected from —O—, —NH—, —N(C1-4 alkyl)-, —CO—, —CO—NH—, —NH—CO—, —S—, —SO—, or —SO2—;
• m is an integer of 0 to 8;
• each R4 is independently selected from C1-4 alkyl, halogen, —CF3, —CN, —OH, —O(C1-4 alkyl), —NH2, —NH(C1-4 alkyl), or —N(C1-4 alkyl)(C1-4 alkyl);
• R5 is aryl or heteroaryl optionally substituted as shown in formula (I), selected from phenyl, benzyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrazolyl, imidazolyl, pyrrolyl, triazinyl, tetrazolyl, thiophenyl (thienyl), thiazolyl, furanyl (furyl), furazanyl, oxazolyl, isoxazolyl, benzthienyl, benzfuryl, benzimidazolyl, benzthiazolyl, isothiazolyl, benzisothiazolyl, benzoxazolyl, benzisoxazolyl, isothiazolyl, benztriazolyl, thiadiazolyl, oxadiazolyl, indolyl indazolyl, chinolinyl, naphthyl, anthracenyl;
• or a pharmaceutically acceptable salt, solvate or prodrug thereof.