Pharmaceutical compositions comprising poh derivatives
AssigneeNeOnc Technologies, Inc.
InventorsThomas Chen, Daniel Levin, Satish Puppali
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Abstract
The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
Claims29
A pharmaceutical composition comprising a perillyl alcohol carbamate.
A method for treating a disease in a mammal, comprising the step of delivering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate.
A process for making a POH carbamate, comprising the step of reacting a first reactant of perillyl chloroformate with a second reactant selected from the group consisting of dimethyl celocoxib (DMC), temozolomide (TMZ) and rolipram.
Dependencies are inferred from the claim text.