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US 2013/0210870 A1Published application
Desferrithiocin polyether analogues
AssigneeUniversity of Florida Research Foundation, Inc.
InventorRaymond J. Bergeron, JR.
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AssigneeUniversity of Florida Research Foundation, Inc.
InventorRaymond J. Bergeron, JR.
Estimating the term…
A relatively non-toxic desazadesferrithiocin analog having the formula: wherein: R1, R2, R4 and R5 may be the same or different and may be H, straight or branched chain alkyl having up to 14 carbon atoms, e.g., methyl, ethyl, propyl and butyl, or arylalkyl wherein the aryl portion is hydrocarbyl and the alkyl portion is straight or branched chain, the arylalkyl group having up to 14 carbon atoms, R2 optionally being alkoxy having up to 14 carbon atoms; R3 is [(CH2)n—O]x—[(CH2)n—O]y-alkyl; n is, independently, an integer from 1 to 8; x is an integer from 1 to 8; y is an integer from 0 to 8, and R3O may occupy any position on the phenyl ring except the 4-position, or a salt, hydrate or solvate thereof; and methods and compositions for treating the effects of trivalent metal, i.e., iron, overload.
A desazadesferrithiocin analog having the formula:
5-6. (canceled)
A method of claim 42, wherein said pathological condition is iron overload.
A method of claim 42, wherein said pathological condition is diabetes.
A method of claim 42, wherein said pathological condition is liver disease.
A method of claim 42, wherein said pathological condition is Friedreich ataxia (FRDA).
A method of claim 42, wherein said pathological condition is heart disease.
A method of claim 42, wherein said pathological condition is cancer.
A method of claim 42, wherein R1 is H or CH3.
A method of claim 42, wherein R2 is H or CH3O.
A method of claim 42, wherein R3—O is O—[(CH2)2—O]3—CH3.
A method of claim 42, said analog having the formula:
(canceled)
A composition of claim 44 wherein said pathological condition is iron overload.
A composition of claim 44 wherein said pathological condition is diabetes.
A composition of claim 44 wherein said pathological condition is liver disease.
A composition of claim 45 wherein said pathological condition is Friedreich ataxia (FRDA).
A composition of claim 44 wherein said pathological condition is heart disease.
A composition of claim 44 wherein said pathological condition is cancer.
A composition of claim 44 wherein R1 is H or CH3.
A composition of claim 44 wherein R2 is H or CH3O.
A composition of claim 44 wherein R3—O is O—[(CH2)2—O]3—CH3.
31-33. (canceled)
4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid, or a salt, hydrate, or solvate thereof.
Dependencies are inferred from the claim text.