New salt of a pyrimidin derivative
AssigneeLaboratorios Senosiain S.A. De C.V.
InventorsJuan Pablo Senosiain Peláez, Héctor Senosiain Arroyo, Manuel Francisco Lara Ochoa
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Abstract
The present invention relates to a salt of a pyrimidin derivative of the acid (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamide)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic, to a method for preparing same and to the use thereof in formulating pharmaceutical formulations.
Claims12
1-9. (canceled)
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamide)-6-(propan-2-yl) pyrimidin-5-yl]-3,5-dihydroxihept-6-enoic amino acid salt, wherein the amino acid is lysine and wherein the bond formed between these two entities is a non-covalent bond.
(3R,5 S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamide)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxihept-6-enoic amino acid salt, wherein the amino acid is histidine and wherein the bond formed between these two entities in a non-covalent bond.
A process for synthesizing a rosuvastatin-lysine salt, comprising the steps:
- a) subjecting the rosuvastatin calcium salt to a dissociation process;
- and
- b) mixing the acid rosuvastatin resulting from the previous step with an aqueous solution containing lysine for forming the salt in the presence of a methanol/ethyl acetate solution.
Dependencies are inferred from the claim text.