Compounds and Their Use as BACE Inhibitors

A compound according to formula (I):

• A is —O— or —CH2—;
• n is 0 or 1;
• R1 is C1-6alkyl or C1-6haloalkyl;
• R2 is hydrogen, C0-6alkylaryl, C0-6alkylheteroaryl, C2-6alkynyl, C2-6alkenyl, C1-6alkyl, halogen, cyano, C1-6haloalkyl, NHC(O)R9 or OR8, wherein:
• said C0-6alkylaryl, C0-6alkyl heteroaryl, C2-6alkynyl, C2-6alkenyl, C1-6alkyl or C1-6haloalkyl is optionally substituted with one to three R7;
• as to R5 and R6:
• R5 and R6 are independently hydrogen, heterocyclyl, C3-6cycloalkyl, aryl, heteroaryl or C1-6alkyl, wherein:
• said heterocyclyl, C3-6cycloalkyl, aryl, heteroaryl or C1-6alkyl is optionally substituted with one or two substituents independently selected from halogen, C1-6alkyl, C1-6haloalkyl, cyano or OR8;
• or
• R5 and R6, together with the carbon to which they are attached, form a ring B, wherein ring B is:
• a 3-14 membered cycloalkyl or heterocyclyl monocyclic ring, or a 9-14 membered bicyclic cycloalkyl or heterocyclyl ring;
• optionally substituted by one or two substituents independently selected from oxo, halogen, C1-6alkyl, C1-6haloalkyl, cyano, or OR8;
• and optionally fused with an aryl or heteroaryl to form a bi- or polycyclic system;
• each R7 is independently C1-6alkyl, halogen, cyano, C0-6alkylC3-6cycloalkyl, C1-6haloalkyl, OC1-6alkyl, OC1-6haloalkyl, C2-6alkynyl or C2-6alkenyl, wherein:
• said C1-6alkyl, C0-6alkylC3-6cycloalkyl, C1-6haloalkyl, OC1-6alkyl, OC1-6haloalkyl, C2-6alkynyl or C2-6alkenyl is optionally substituted with 1-3 substituents independently selected from halogen, cyano, C1-6alkyl, C1-6haloalkyl, OC1-6alkyl and OC1-6haloalkyl;
• each R8 is independently hydrogen, C1-6alkyl, C2-6alkynyl, C1-6haloalkyl, aryl or heteroaryl, wherein:
• said C1-6alkyl, C1-6haloalkyl, aryl or heteroaryl is optionally substituted with a group selected from halogen, cyano and C1-6alkyl;
• and
• R9 is a heteroaryl, wherein:
• said heteroaryl is optionally substituted with halogen, cyano, OR8, C1-6haloalkyl or C1-6alkyl;
• or a pharmaceutically acceptable salt thereof.