Indirubin derivatives and uses thereof in treating chronic myelogenous leukemia

A method of treating CML in a subject comprising administering to the subject at least one indirubin derivative compound or a pharmaceutical composition thereof, wherein the at least one indirubin derivative compound comprises a structure of Structure A:

• and the pharmaceutically acceptable solvates, salts and stereoisomers thereof, including mixtures thereof in all ratios, wherein:
• X is C or N;
• RX is selected from the group consisting of nothing, H, halogen, and haloalkyl;
• R6 is selected from the group consisting of H, halogen, substituted and unsubstituted alkylamino, and substituted and unsubstituted alkoxy;
• R5 is selected from the group consisting of H, halogen, nitro, amino, substituted and unsubstituted alkylamino, and substituted and unsubstituted alkyl;
• Y is N or O;
• when Y is N, RY is selected from the group consisting of nothing, H, hydroxy, alkoxy, haloalkoxy, substituted and unsubstituted —O—C(═O)—N(R′)R″, substituted and unsubstituted —O—C(═O)—R0, and —O—R—R′;
• when Y is O, RY is nothing;
• R′5 is selected from the group consisting of H, alkoxy, nitro, —CN, —C(═O)—O—R0, —C(═O)—OH, —C(═O)H, heteroaryl, —C═N—OH and —R—OH;
• R′6 is selected from the group consisting of H, halogen, alkyl and —C(═O)—O—R0;
• more preferably H;
• Z is N or S;
• more preferably N;
• Rz is selected from the group consisting of H, O, —C(═O)—R0, and R0;
• more preferably H or R0;
• each R is independently nothing or substituted or unsubstituted alkylenyl;
• each R0 is independently substituted or unsubstituted alkyl;
• each R0 is independently substituted or unsubstituted alkyl;
• more preferably methyl, ethyl, or —(CH2)—CH2(OH)—CH2OH;
• and
• each R′ and R″ are independently selected from the group consisting of H, substituted and unsubstituted alkyl, substituted and unsubstituted alkoxy, substituted and unsubstituted alkylamino, substituted and unsubstituted haloalkyl, substituted and unsubstituted heterocyclyl, substituted and unsubstituted aryl and substituted and unsubstituted heteroaryl.