Substituted imidazo[1,2-b]pyridazines

A compound of formula (II),

• wherein
• Rx is R6 or a protecting group,
• Ry is hydrogen or a protecting group,
• whereby Rx and Ry together, or Y and Rx together, may form a cyclic protecting group,
• R1 is hydrogen, halogen, 2-6C-alkenylen-C(O)NH2, 2-6C-alkenylen-C(O)OR10, or a group selected from 1-6C-alkyl, 2-6C-alkenyl, 3-7C-cycloalkyl, aryl, heteroaryl, wherein said group being optionally substituted, one or more times, identically or differently, with a substituent selected from:
• hydroxy, halogen, 1-6C-alkyl, 1-4C-haloalkyl, 1-4C-hydroxyalkyl, 1-6C-alkoxy, —NR8R9, cyano, —C(O)NR8R9, —C(O)OR10, —NHC(O)R11, —NHS(O)2R11, —S(O)2R11, —S(O)2NR8R9,
• R2 is hydrogen, halogen, cyano, or a group selected from 1-6C-alkyl, 3-7C-cycloalkyl,
• wherein said 1-6C-alkyl being optionally substituted, one or more times, identically or differently, with a substituent selected from:
• hydroxy, halogen, 1-6C-alkoxy,
• R3 is hydrogen, 1-6C-alkyl, 3-7C-cycloalkyl,
• R4 is phenyl optionally substituted, one or more times, identically or differently, with a substituent selected from:
• 1-6C-alkyl, halogen, cyano,
• R5 is hydrogen, halogen,
• R6 is hydrogen, 1-6C-alkyl,
• R8, R9 which can be the same or different, is hydrogen, 1-4C-alkyl or 3-7C-cycloalkyl, wherein said 1-4C-alkyl and 3-7C-cycloalkyl is optionally substituted in the same way of differently one or more times with halogen, hydroxy, mono- or di-1-4C-alkylamino, 1-4C-alkoxy,
• or,
• in the case of —NR8R9, R8 and R9 together with the nitrogen to which they are attached may also form a 3-6C-heterocyclic ring,
• R10 is hydrogen, 1-6C-alkyl,
• R11 is 1-4C-alkyl (optionally substituted in the same way of differently one or more times with halogen, hydroxy) or 3-7C-cycloalkyl,
• X is (CH2)n—,
• n is 0, 1, 2, or 3, and
• Y is —CH2—, —CH(OH)—.