Aqueous Pharmaceutical Composition With Enhanced Stability
AssigneeAlcon Research, Ltd.
InventorsDavid L. Meadows, Howard Allen Ketelson, Jang-Shing Chiou, James W. Davis
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Abstract
The present invention is an aqueous pharmaceutical composition that includes an ionized therapeutic agent, an ionic component and guar gum. The guar gum is present in the composition a concentration sufficient to limit interactions between the ionized therapeutic agent and the ionic component thereby imparting stability to the composition. The composition is preferably at or near physiologic pH. The aqueous pharmaceutical composition has been found particularly useful as an aqueous ophthalmic, otic or nasal composition. The pharmaceutical composition, due to its characteristics, is particularly suitable as an ophthalmic composition.
Claims20
An aqueous pharmaceutical composition, comprising:
- an ionized therapeutic agent;
- an ionic component;
- guar gum at a concentrations sufficient to limit interactions between the ionized therapeutic agent and the ionic component thereby imparting stability to the composition;
- and
- water;
- wherein the composition has a pH that is at least 6.0, but is no greater than 8.3.
An aqueous pharmaceutical composition, comprising:
- an ionized therapeutic agent wherein the ionized therapeutic agent is an antihistaminic agent;
- an ionic component wherein the ionic component includes preservative is selected from the group consisting of a polymeric quaternary ammonium compound and benzalkonium chloride;
- a cyclodextrin as a solubilizing agent;
- guar gum at a concentrations sufficient to limit interactions between the ionized therapeutic agent and the ionic component thereby imparting stability to the composition;
- and
- water;
- wherein the composition has a pH that is at least 6.0, but is no greater than 8.3.
Dependencies are inferred from the claim text.