Picolinamide and pyrimidine-4-carboxamide compounds, process for preparing and phamaceutical composition comprising the same

An amide compound represented by the formula 1 below, or a pharmaceutically acceptable salt, solvate, hydrate, prodrug, racemate, or stereoisomer thereof.

• [In the formula 1,
• X represents N or CR, and Y represents N or CH, provided that X and Y are not carbon at the same time;
• Z represents N or CH;
• R1 and R2 independently represent hydrogen, (C1-C10)alkyl, (C3-C10)cycloalkyl, norbornyl, adamantyl, noradamantyl, (C6-C20)aryl, (C6-C20)ar(C1-C10)alkyl, or (C3-C20)heteroaryl, or R1 and R2 may be linked to each other, together with nitrogen atoms to which they are bound, to form (C1-C10) saturated or unsaturated heterocycle, biheterocycle or fused heterocycle, provided that both R1 and R2 are not hydrogen at the same time;
• L represents a single bond, —O—, —NR11—, —CO—, —SO2—, —(CR21R22)—(CH2)c— (c represents an integer of 0 to 5), —CO(CR21R22)d— (d represents an integer of 1 to 6), (C3-C10)cycloalkylene, (C6-C20)arylene or (C3-C20)heteroarylene;
• R21 and R22 independently represent hydrogen or (C1-C10)alkyl, or R21 and R22 may be linked via alkylene or alkenylene to form a cycloaliphatic ring or an aromatic ring;
• R and R3 independently represent hydrogen, (C1-C10)alkyl, (C3-C10)cycloalkyl, (C1-C10)alkoxy, halogen, hydroxy, cyano, —NR31R32, nitro, —CONH2, —CO2R33, —SO3H, —SO2NR34R35, —SO2R36, —O(CH2)aCO2H (a represents an integer of 1 to 3), —O(CH2)bCONH2 (b represents an integer of 1 to 3), —NH(CO)R37, —NH(SO2)R38, 5- to 7-membered heterocycle, (C6-C20)aryl or (C3-C20)heteroaryl;
• R4 and R5 independently represent hydrogen, (C1-C10)alkyl, (C3-C10)cycloalkyl, (C1-C10)alkoxy, halogen, hydroxy, cyano, amino, nitro, —CONH2 or —CO2R12, and include all of isomers and racemic compounds thereof all, or R4 and R5 may be substituted with adjacent carbon atoms to form (C1-C10) saturated or unsaturated carbocycle, heterocycle, bicarbocycle, biheterocycle, fused carbocycle, or fused heterocycle, or may be linked to R3 to form saturated or unsaturated carbocycle;
• R6 and R7 independently represent hydrogen, (C1-C10)alkyl, (C3-C10)cycloalkyl, (C1-C10)alkoxy, halogen, hydroxy, cyano, amino, nitro, —CONH2 or —CO2R12;
• the cycloalkylene, arylene or heteroarylene of L;
• the alkyl, cycloalkyl, norbornyl, adamantyl, noradamantyl, aryl, aralkyl or heteroaryl of R1 and R2;
• the saturated or unsaturated heterocycle, biheterocycle or fused heterocycle formed by the linkage of R1 and R2;
• the alkyl, cycloalkyl, alkoxy, heterocycle, aryl or heteroaryl of R and R3;
• the alkyl, cycloalkyl or alkoxy of R4 and R5;
• the saturated or unsaturated carbocycle, heterocycle, bicarbocycle, biheterocycle, fused carbocycle or fused heterocycle formed by the substitution of R4 and R5 with adjacent carbon atoms;
• and the alkyl, cycloalkyl or alkoxy of R6 and R7 may be further substituted with one or more substituent(s) selected from the group consisting of (C1-C10)alkyl, (C3-C10)cycloalkyl, (C1-C10)alkoxy, halo(C1-C10)alkyl, halo(C1-C10)alkoxy, halogen, hydroxy, cyano, —NR41R42, nitro, —CO2R43, —CONH2, —SO3H, —SO2NR44R45, —SO2(CH2)cNR44R45 (c represents an integer of 1 to 3), —SO2R46, —O(CH2)cCO2H (c represents an integer of 1 to 3), —O(CH2)dCONH2 (d represents an integer of 1 to 3), —NH(CO)R47, —NH(SO2)R48, (C6-C20)aryl and (C3-C20)heteroaryl;
• R11, R12, R31, R32, R33, R34, R35, R36, R37, R38, R41, R42, R43, R44, R45, R46, R47 and R48 independently represent hydrogen, (C1-C10)alkyl, (C3-C10)cycloalkyl or (C6-C20)aryl;
• and
• m and n independently represent an integer of 0 to 3, provided that m+n represents an integer of 2 or more.]