Protein Kinase C Inhibitors and Uses Thereof

A compound of the formula (I):

• wherein
• R5 is selected from alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, amino, substituted amino, carboxyl, carboxyl ester, cyano, halogen, acyl, aminoacyl, nitro, alkenyl, substituted alkenyl, alkynyl, and substituted alkynyl;
• Y is selected from hydrogen and alkyl;
• R1 is selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, acyl, and oxy radical;
• Ra and Rb are independently selected from hydrogen and alkyl;
• Rc and Rd are independently selected from hydrogen and alkyl;
• Q is selected from N and CR7b;
• R7a, R7b, and R8 are independently selected from hydrogen, alkyl, substituted alkyl, halogen, cyano, hydroxyl, alkoxy, substituted alkoxy, amino, substituted amino, acylamino, aminocarbonyloxy, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, alkoxycarbonylamino, aminocarbonylamino, acyl, carboxyl, carboxyl ester, aminoacyl, sulfonyl, sulfonylamino, aminosulfonyl, and —O-alk-A;
• alk, if present, is alkyl or substituted alkyl;
• A is selected from aryl, cycloalkyl, heteroaryl, and heterocyclyl;
• wherein the A ring can be substituted or unsubstituted;
• or
• wherein two of R7a, R7b, and R8 together with the carbon atom to which they are attached form a carbocyclic or heterocyclic 4 to 8-membered ring, wherein the carbocyclic or heterocyclic 4 to 8-membered ring is unsubstituted or substituted;
• or a salt or stereoisomer thereof.