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US 2013/0210799 A1Published application
Novel azetidine derivatives
AssigneeHoffmann-La Roche Inc.
InventorsLilli Anselm, David Banner, Wolfgang Haap, Bernd Kuhn, Thomas Luebbers, Jens-Uwe Peters, Beat Spinnler
Life of this patent
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Abstract
The invention relates to a compound of formula (I) wherein A1, A2 and R1 to R8 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
Claims19
A compound of formula (I)
- wherein
- one of A1 and A2 is —NR9— and the other one is —CH2—;
- R1 is halogen;
- R2 is hydrogen, halogen, alkyl or haloalkyl;
- R3 is hydrogen, halogen, alkyl or haloalkyl;
- R4 and R5 are both hydrogen at the same time;
- or R4 and R5 together with the carbon atom to which they are attached form cycloalkyl;
- R6 is hydrogen, halogen, alkyl, haloalkyl or cycloalkyl;
- R7 is hydrogen, halogen, alkyl, haloalkyl or cycloalkyl;
- R8 is hydrogen, alkyl, haloalkyl, alkoxy, haloalkoxy, cycloalkyl, alkylpyrdinyl, alkyl-1H-pyrazolyl, phenyl, substituted phenyl, heterocyclyl or substituted heterocyclyl, wherein heterocyclyl is pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiophenyl, thiazolyl, thiadiazolyl, piperidinyl, piperazinyl, pyrrolidinyl or morpholinyl, wherein substituted phenyl is phenyl substituted with one to three substituents independently selected from alkyl, halogen, cycloalkyl, haloalkyl, alkoxy, haloalkoxy, halocycloalkyl and nitrile and wherein substituted heterocyclyl is heterocyclyl substituted with one to three substituents independently selected from alkyl, halogen, cycloalkyl, haloalkyl, alkoxy, haloalkoxy, halocycloalkyl and nitrile;
- and
- R9 is hydrogen, alkyl, haloalkyl, cycloalkyl, acyl or alkoxycarbonyl;
- or a pharmaceutically acceptable salt or ester thereof.
10 more elements
Dependencies are inferred from the claim text.