Substituted dicyanopyridines and use thereof

A compound of the formula (I)

• in which
• A represents oxygen or sulfur,
• G represents CH or N,
• K represents CH, CF or N,
• L represents CR6 or N,
• where
• R6 represents hydrogen, fluorine, chlorine, difluoromethyl, trifluoromethyl or (C1-C4)-alkoxy,
• where (C1-C4)-alkoxy may be substituted by 1 or 2 hydroxyl substituents,
• M represents CR7 or N,
• where
• R7 represents hydrogen, fluorine, chlorine, difluoromethyl, trifluoromethyl or (C1-C4)-alkoxy,
• where (C1-C4)-alkoxy may be substituted by 1 or 2 hydroxyl substituents,
• with the proviso that at most two of the groups K, L or M represent N,
• R1 represents hydrogen or (C1-C4)-alkyl,
• R2 represents hydroxycarbonyl, aminocarbonyl, mono-(C1-C4)-alkylaminocarbonyl, di-(C1-C4)-alkylaminocarbonyl, (C3-C7)-cycloalkyl-aminocarbonyl, aminosulfonyl, (C1-C4)-alkylsulfonylamino or phenylsulfonylamino,
• where mono-(C1-C4)-alkylaminocarbonyl, di-(C1-C4)-alkylaminocarbonyl and (C3-C7)-cycloalkylaminocarbonyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, hydroxy and amino,
• R3 represents hydrogen, fluorine or methoxy,
• R4 represents hydrogen, fluorine, (C1-C6)-alkoxy, mono-(C1-C4)-alkylamino, di-(C1-C4)-alkylamino, (C1-C4)-alkylcarbonylamino, mono-(C1-C4)-alkylamino sulfonyloxy, di-(C1-C4)-alkylaminosulfonyloxy or 2-oxopyrrolidin-1-yl,
• where (C1-C6)-alkoxy may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of trifluoromethyl, hydroxy, (C1-C4)-alkoxy, amino, mono-(C1-C4)-alkylamino, di-(C1-C4)-alkylamino, aminocarbonyl, mono-(C1-C4)-alkylaminocarbonyl, di-(C1-C4)-alkylaminocarbonyl and a group of the formula
• in which
• # represents the point of attachment to the alkoxy group,
• R10 represents hydrogen or the side group of a natural α-amino acid or its homologs or isomers,
• or
• R4 and R6 together with the carbon atoms to which they are attached form a group of the formula —O—CH2—O—, —O—CHF—O—, —O—CF2—O—, —O—CH2—CH2—O— or —O—CF2—CF2—O—,
• or
• R4 and R7 together with the carbon atoms to which they are attached form a group of the formula —O—CH2—O—, —O—CHF—O—, —O—CF2—O—, —O—CH2—CH2—O— or —O—CF2—CF2—O—,
• R5 represents hydrogen or —NR8R9,
• where
• R8 represents hydrogen or (C1-C4)-alkyl,
• R9 represents hydrogen, (C1-C6)-alkyl or (C3-C7)-cycloalkyl,
• where (C1-C6)-alkoxy may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, difluoromethyl, trifluoromethyl, hydroxy and (C1-C4)-alkoxy,
• or
• R8 and R9 together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocycle,
• where the 4- to 7-membered heterocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, hydroxy and 4- to 7-membered heterocycle,
• or an N-oxide, solvate, salt of the N-oxide and solvate of the N-oxide or a salt thereof,
• except for the compounds
• 4-{[(6-amino-3,5-dicyano-4-phenylpyridin-2-yl)sulfanyl]methyl}-N-methylpyridine-2-carboxamide
• 3-[({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)methyl]benzoic acid
• 3-{[(6-amino-3,5-dicyano-4-phenylpyridin-2-yl)sulfanyl]methyl}benzoic acid.