Method of treating disorder related to high cholesterol concentration
AssigneeThe University of Chicago
InventorsChing Song, Shutsung Liao, Qing Dai
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Abstract
A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and compositions for treating a disorder in a subject where an activator of liver X alpha is indicated, such as in, for example, treating a high cholesterol disease.
Claims20
A method for lowering blood cholesterol levels in a subject, comprising administering to the subject a compound of formula (I):
- wherein
- R1, R2, R3, R4, R5, R6, R7, R11, R12, R15, R16, and R20 are independently hydrogen, halo, alkyl, haloalkyl, hydroxyl, amino, carboxyl, oxo, or sulfonic acid;
- R8, R9, R10, R13, and R14 are independently hydrogen, halo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxyl, or amino;
- n is 0, 1, or 2;
- A is alkenylene;
- and
- X, Y, and Z are independently alkyl, haloalkyl, or —OR′, R′ being hydrogen, alkyl, or haloalkyl;
- or a salt, an ester, an amide, an enantiomer, an isomer, a tautomer, or a polymorph thereof.
A method for relieving a vascular disorder associated with high blood cholesterol levels in a subject, comprising administering to the subject a compound of formula (I):
- wherein
- R1, R2, R3, R4, R5, R6, R7, R11, R12, R15, R16, and R20 are independently hydrogen, halo, alkyl, haloalkyl, hydroxy, amino, carboxyl, oxo, or sulfonic acid;
- R8, R9, R10, R13, and R14 are independently hydrogen, halo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, or amino;
- n is 0, 1, or 2;
- A is alkenylene;
- and
- X, Y, and Z are independently alkyl, haloalkyl, or —OR′;
- R′ being hydrogen, alkyl, or haloalkyl;
- or a salt, an ester, an amide, an enantiomer, an isomer, a tautomer, or a polymorph-thereof.
Dependencies are inferred from the claim text.