Treatment of l-dopa, dopamine agonist and/or dopamine enhancer induced disorders
OwnerPatrick Alexander Howsoninventor
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Abstract
One or more agent selected from A/B-cis furostane, furostene, spirostane and spirostene steroidal sapogenins and ester, ether, ketone or glycosylated forms thereof, including E and/or F ring opened derivatives thereof, is used to treat or prevent L-DOPA, dopamine agonist and/or dopamine enhancer induced disorders, such as L-DOPA induced dyskinesia (LID), which is a side effect of L-DOPA, dopamine agonist and/or dopamine enhancer therapies, e.g., for Parkinson's disease. The agent according to the invention may be administered in association with the therapeutic agent for the treatment of the Parkinson's disease or another dopamine-responsive disorder.
Claims23
A method of treating or preventing L-DOPA, dopamine agonist and/or dopamine enhancer induced disorders in a subject in need thereof, comprising administering to the subject an effective amount of one or more agent selected from A/B-cis furostane, furostene, spirostane and spirostene steroidal sapogenins and ester, ether, ketone and glycosylated forms thereof, including E and/or F ring opened derivatives thereof, wherein the L-DOPA, dopamine agonist and/or dopamine enhancer induced disorder is selected from dyskinesia, hypotension, arrhythmias, nausea, disturbed respiration, sleep disorders (for example, somnolence, insomnia and vivid dreams), dopamine dysregulation syndrome, hallucinations, and neuropsychiatric problems such as risk-taking, gambling tendency, impulse control disorders, anxiety, disorientation and confusion, psychosis and any combination thereof.
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A composition comprising one or more active agent selected from A/B-cis furostane, furostene, spirostane and spirostene steroidal sapogenins, and ester, ether, ketone and glycosylated forms thereof, including E and/or F ring opened derivatives thereof;
- and L-DOPA, a dopamine agonist and/or a dopamine enhancer.
A method of treating Parkinson's disease using a combination of L-DOPA, a dopamine agonist and/or a dopamine enhancer and one or more active agent selected from A/B-cis furostane, furostene, spirostane and spirostene steroidal sapogenins, and ester, ether, ketone and glycosylated forms thereof, including E and/or F ring opened derivatives thereof.
Dependencies are inferred from the claim text.