Combinations and methods for treating non age-related hearing impairment in a subject
AssigneeWashington University
InventorsJianxin Bao, Richard Chole
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Abstract
The present invention generally relates to treating non age-related hearing impairments. More specifically, the present invention provides combinations and methods for treatment and prevention of non age-related hearing impairment in a subject.
Claims22
A combination, the combination comprising a glucocorticosteroid and an antiepileptic drug selected from the group consisting of an oxazolidinedione, a sulfonamide, and a succinimide, in an amount therapeutically effective to treat or prevent non age-related hearing impairments in a subject, wherein the therapeutically effective amount of the glucocorticosteroid comprises a dose ranging from about 1 to about 50 mg/kg of the body weight of the subject, and the therapeutically effective amount of the antiepileptic comprises a dose ranging from about 20 to about 350 mg/kg of the body weight of the subject.
A method for treating or preventing a non age-related hearing impairment in a subject in need of such treatment, the method comprising administering a combination comprising a glucocorticosteroid and an antiepileptic drug selected from the group consisting of an oxazolidinedione, a sulfonamide, and a succinimide, to a subject in an amount therapeutically effective to treat a non age-related hearing impairment in the subject, wherein the therapeutically effective amount of the glucocorticosteroid comprises a dose ranging from about 1 to about 50 mg/kg of the body weight of the subject, and the therapeutically effective amount of the antiepileptic comprises a dose ranging from about 20 to about 350 mg/kg of the body weight of the subject.
Dependencies are inferred from the claim text.