Pharmaceutical formulations
AssigneeAnacor Pharmaceuticals, Inc.
InventorsStephen J. Baker, Kirk R. Maples, Tsutomu Akama, Virginia Sanders, Yong-Kang Zhang, Jacob J. Plattner, David P. Perry
Life of this patent
Estimating the term…
Abstract
This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
Claims11
-19. (canceled)
A pharmaceutical formulation comprising:
- a) a pharmaceutically acceptable excipient which is alcohol;
- b) a compound which penetrates the nail plate and travels through the nail plate to a nail bed underlying said nail plate;
- c) an emollient which is a cyclic polydimethylsiloxane containing from about 3 to about 9 silicon atoms;
- and
- having an efficacy coefficient against having an efficacy coefficient against Trichophyton rubrum or Trichophyton mentagrophytes above 10;
- wherein the compound is present in said pharmaceutical formulation in a concentration of from about 0.5% to about 15%;
- and
- wherein said pharmaceutical formulation is for ungual administration to a human suffering from onychomycosis mediated at least in part by said Trichophyton rubrum or Trichophyton mentagrophytes.
Dependencies are inferred from the claim text.