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US 2013/0210760 A1Published application
Dermal filler compositions including antioxidants
AssigneeAllergan, Inc.
InventorsFutian Liu, Xiaojie Yu, Nicholas J. Manesis, Athene Wan Chie Chan
Life of this patent
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Abstract
Provided are injectable, hyaluronic acid-based dermal filler compositions including conjugated vitamin C derivatives. The compositions provide for extended release of active vitamin C into tissue, promoting collagenesis and other benefits to skin.
Claims20
A method for treatment of skin, comprising:
- introducing a composition into the skin of a patient, the composition comprising hyaluronic acid and a vitamin C derivative covalently conjugated to the hyaluronic acid, wherein a degree of conjugation is between about 3 mol % and about 40 mol %, thereby achieving improved collagenesis in the skin.
A method for treatment of wrinkles, scars or defects in skin of a patient, comprising:
- introducing a composition into the skin adjacent a wrinkle, scar or defect in the skin, the composition comprising crosslinked hyaluronic acid and a vitamin C derivative covalently conjugated to the hyaluronic acid, wherein a degree of conjugation is between about 3 mol % and about 40 mol %, thereby achieving reduced appearance of the wrinkle, scar or defect.
An injectable composition for improving the appearance of skin in a patient, the composition comprising:
- a hyaluronic acid crosslinked with 1,4-butanediol diglycidyl ether (BDDE), the hyaluronic acid present in the composition at a concentration of between about 10 mg/ml to about 20 mg/ml;
- L-ascorbic acid 2-glucoside (AA2G) covalently conjugated to the hyaluronic acid, a degree of conjugation being between about 3 mol % and about 40 mol %;
- and lidocaine mixed with the hyaluronic acid and present in the composition in an amount of between about 0.1% to about 1.0%;
- wherein the composition has a G′ of about 200 Pa at 1 Hz.
1 more element
Dependencies are inferred from the claim text.