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US 2013/0210748 A1Published application
Method and peptide for regulating cellular activity
AssigneesOregon Health & Science University, United States of America, as represented by the U.S. Department of Veterans Affairs
InventorsSteven H. Hefeneider, Sharon L. McCoy
Life of this patent
Estimating the term…
Abstract
Method and peptide for regulating cellular activity includes a panel of synthesized peptides that have biological effects on inhibiting or enhancing cellular activity. Selected peptides can be used as therapy to reduce and/or inhibit, or initiate and/or enhance, an inflammatory response in a subject.
Claims22
An isolated polypeptide, consisting of:
- (a) the amino acid sequence set forth as SEQ ID NO:
- 1, the amino acid sequence set forth as SEQ ID NO:
- 10, the amino acid sequence set forth as SEQ ID NO:
- 4, the amino acid sequence set forth as SEQ ID NO:
- 2, the amino acid sequence set forth as SEQ ID NO:
- 3, the amino acid sequence set forth as SEQ ID NO:
- 5, the amino acid sequence set forth as SEQ ID NO:
- 9, the amino acid sequence set forth as SEQ ID NO:
- 11, the amino acid sequence set forth as SEQ ID NO:
- 12, or the amino acid sequence set forth as SEQ ID NO:
- 15;
- or
- (b) the amino acid sequence set forth as SEQ ID NO:
- 1, the amino acid sequence set forth as SEQ ID NO:
- 10, the amino acid sequence set forth as SEQ ID NO:
- 4, the amino acid sequence set forth as SEQ ID NO:
- 2, the amino acid sequence set forth as SEQ ID NO:
- 3, the amino acid sequence set forth as SEQ ID NO:
- 5, the amino acid sequence set forth as SEQ ID NO:
- 9, the amino acid sequence set forth as SEQ ID NO:
- 11, the amino acid sequence set forth as SEQ ID NO:
- 12, or the amino acid sequence set forth as SEQ ID NO:
- 15, covalently linked to the transducing amino acid sequence set forth as SEQ ID NO:
- 22.
21 more elements
A method of reducing or inhibiting Toll Like Receptor (TLR)-induced inflammation, comprising:
- administering to a subject in need thereof, an effective amount of:
- a) a peptide consisting of the amino acid sequence set forth as SEQ ID NO:
- 1, the amino acid sequence set forth as SEQ ID NO;
- 10, the amino acid sequence set forth as SEQ ID NO:
- 4, the amino acid sequence set forth as SEQ ID NO:
- 2, the amino acid sequence set forth as SEQ ID NO:
- 3, the amino acid sequence set forth as SEQ ID NO:
- 5, the amino acid sequence set forth as SEQ ID NO:
- 9, the amino acid sequence set forth as SEQ ID NO:
- 11, the amino acid sequence set forth as SEQ ID NO:
- 12, or the amino acid sequence set forth as SEQ ID NO:
- 15;
- or
- b) a peptide consisting of the amino acid sequence set forth as SEQ ID NO:
- 1, the amino acid sequence set forth as SEQ ID NO:
- 10, the amino acid sequence set forth as SEQ ID NO:
- 4, the amino acid sequence set forth as SEQ ID NO:
- 2, the amino acid sequence set forth as SEQ ID NO:
- 3, the amino acid sequence set forth as SEQ ID NO:
- 5, the amino acid sequence set forth as SEQ ID NO:
- 9, the amino acid sequence set forth as SEQ ID NO:
- 11, the amino acid sequence set forth as SEQ ID NO:
- 12, or the amino acid sequence set forth as SEQ ID NO:
- 15, covalently linked to the transducing amino acid sequence set forth as SEQ ID NO:
- 22;
- thereby reducing or inhibiting Toll Like Receptor (TLR)-induced inflammation.
23 more elements
Dependencies are inferred from the claim text.