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US 2013/0210734 A1Published application
Method of preventing progression of hypertension-induced heart failure with pkc peptides
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsDaria D. Mochly-Rosen, Koichi K. Inagaki
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Abstract
Methods are described for slowing or inhibiting the progression of heart failure in a mammalian subject suffering from chronic hypertension. The methods involve administering an εPKC, β1PKC, or βIIPKC peptide inhibitor, examples of which are provided.
Claims8
A method for slowing or inhibiting the progression of heart failure in a mammalian subject suffering from chronic hypertension, comprising:
- administering to the subject a therapeutically effective amount of a βIIPKC peptide inhibitor from the V5 domain ofβIIPKC, wherein the βIIPKC peptide inhibitor specifically inhibits βIIPKC.
Dependencies are inferred from the claim text.