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US 2013/0210726 A1Published application
Compositions and methods for treatment of peripheral vascular disease
AssigneeTarix Pharmaceuticals Ltd.
InventorRichard Franklin
Life of this patent
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Abstract
The present invention relates to compositions and methods for the treatment of peripheral vascular disease (PVD). In particular, the invention provides compositions and methods for treatment of critical limb ischemia, and related diseases, disorders or conditions, based on the use of angiotensin-(1-7) peptides or functional equivalents, analogs or derivatives, angiotensin-(1-7) receptor agonists, ACE2 and/or ACE2 activators.
Claims30
A method for treating peripheral vascular disease comprising a step of
- administering a pharmaceutical composition comprising an angiotensin (1-7) peptide to an individual suffering from a peripheral vascular disease characterized by partial or complete blockage of blood flow to one or more tissues outside the heart and brain, wherein the angiotensin (1-7) peptide is administered in a therapeutically effective amount such that at least one symptom or feature of the peripheral vascular disease is reduced in intensity, severity, or frequency, or has delayed onset.
A method for treating peripheral vascular disease comprising a step of
- administering a pharmaceutical composition comprising an angiotensin-(1-7) receptor agonist to an individual suffering from a peripheral vascular disease characterized by partial or complete blockage of blood flow to one or more tissues outside the heart and brain,
- wherein the angiotensin-(1-7) receptor agonist has a formula of
Dependencies are inferred from the claim text.