Use of the Insulin-Like-Growth Factor 1 Splice Variant MGF for the Prevention of Myocardial Damage
AssigneeThe Board of Trustees of the University of Illinois
InventorsGeoffrey Goldspink, Paul Goldspink
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Abstract
The invention relates to the use of a Mechano Growth Factor (MGF) polypeptide or a polynucleotide encoding an MGF polypeptide in the manufacture of a medicament for the prevention or limitation of myocardial damage in response to ischemia or mechanical overload of the heart by preventing or limiting apoptosis in the myocardium.
Claims16
1-20. (canceled)
A method for preventing or limiting myocardial damage in response to a heart attack, comprising administering to a subject in need thereof a Mechano Growth Factor (MGF) polypeptide or a polynucleotide encoding an MGF polypeptide in an amount effective to prevent or limit myocardial apoptosis.
Dependencies are inferred from the claim text.