CXCR4 Receptor Compounds

A compound represented by Formula B or a pharmaceutically acceptable salt thereof:

• T-L-Y1-Y2-Y3-Y4-Y5-Y6-Y7-Y8-Y9-Y10-Y11-Y12-Y13-Y14-Y15-Y16-Y17-Y18-Y19-Y20-Y21-Y22-Y23-Y24-Y25-R1;
• wherein L is a linking moiety represented by C(O) and bonded to the N terminal nitrogen of Y1 or the next present amino acid residue if Y1 is absent;
• T is a lipophilic tether moiety bonded to L;
• and R1 is OR2 or N(R2)2, each R2 is independently H or alkyl, wherein at least three contiguous Y1-Y25 amino acid residues are present and wherein at least one of Y1-Y22 is absent, a d-amino acid residue or an alanine residue, and wherein:
• Y1 is an aspartic acid residue, a d-aspartic acid residue, an alanine residue or absent,
• Y2 is an arginine residue, a d-arginine residue, an alanine residue or absent,
• Y3 is a tyrosine residue, a d-tyrosine residue, an alanine residue or absent,
• Y4 is a leucine residue a d-leucine residue, an alanine residue or absent,
• Y5 is an alanine residue, a d-alanine residue or absent,
• Y6 is an isoleucine residue, a d-isoleucine residue, an alanine residue or absent,
• Y7 is a valine residue, a d-valine acid residue, an alanine residue or absent,
• Y8 is a histidine residue a d-histidine residue, an alanine residue or absent,
• Y9 is an alanine residue, a d-alanine residue or absent,
• Y10 is a threonine residue, a d-threonine residue, an alanine residue or absent,
• Y1l is an asparagine residue, a d-asparagine residue, an alanine residue or absent,
• Y12 is a serine residue, a d-serine residue, an alanine residue or absent,
• Y13 is a glutamine residue, a d-glutamine residue, an alanine residue or absent,
• Y14 is an arginine residue, a d-arginine residue, an alanine residue or absent,
• Y15 is a proline residue, a d-proline residue, an alanine residue or absent,
• Y16 is an arginine residue, a d-arginine residue, an alanine residue or absent,
• Y17 is a lysine residue, a d-lysine residue, an alanine residue or absent,
• Y18 is a leucine residue, a d-leucine residue, an alanine residue or absent,
• Y19 is a leucine residue, a d-leucine residue, an alanine residue or absent,
• Y20 is an alanine residue, a d-alanine, an isoleucine residue, a d-isoleucine residue, an arginine residue, a d-arginine residue, a valine residue, a d-valine or absent,
• Y21 is a glutamic acid residue, a d-glutamic acid residue, an alanine residue, a d-alanine residue or absent,
• Y22 is a lysine residue, a d-lysine residue, an alanine residue or absent,
• Y23 is a valine residue, a d-valine residue or absent,
• Y24 is a valine residue, a d-valine residue or absent, and
• Y25 is a tyrosine residue, a d-tyrosine residue or absent.

A compound represented by Formula C or a pharmaceutically acceptable salt thereof:

• T-L-W1-W2-W3-W4-W5-W6-W7-W8-W9-W10-W11-W12-W13-W14-W15-W16-W17-W18-W19-W20-W21-W22-W23-W24-W25-W26-W27-W28-W29-W30-W31-W32-R1;
• wherein L is a linking moiety represented by C(O) and bonded to W1 at an N terminal nitrogen of W1 or the next present amino acid residue if W1 is absent;
• T is a lipophilic tether moiety bonded to L;
• R1 is OR2 or N(R2)2, each R2 is independently H or alkyl, wherein at least three contiguous W1-W32 are present, and wherein:
• W1 is an isoleucine residue, a d-isoleucine residue, an alanine residue or absent,
• W2 is isoleucine residue, a d-isoleucine residue, an alanine residue or absent,
• W3 is isoleucine residue, a d-isoleucine residue, an alanine residue or absent,
• W4 is a serine residue, a d-serine residue, an alanine residue or absent,
• W5 is a lysine residue, a d-lysine residue, an alanine residue or absent,
• W6 is a leucine residue, a histidine residue, a d-leucine residue, an alanine residue or absent,
• W7 is a serine residue, a d-serine residue, an alanine residue or absent,
• W8 is a histidine residue, a d-histidine residue, an alanine residue or absent,
• W9 is a serine residue, a d-serine residue, an alanine residue a lysine residue, or absent,
• W10 is a lysine residue, a d-lysine residue, an alanine residue, a leucine residue, an isoleucine residue or absent,
• W11 is glycine residue, a d-glycine residue, an alanine residue or absent,
• W12 is a histidine residue, a d-histidine residue, an alanine residue a tyrosine residue or absent,
• W13 is a glutamine residue, a d-glutamine residue, an alanine residue or absent,
• W14 is a lysine residue, a d-lysine residue, an alanine residue or absent;
• W15 is an arginine residue, a d-arginine residue, an alanine residue, a lysine residue or absent,
• W16 is a lysine residue, a d-lysine residue, an alanine residue, a leucine residue or absent,
• W17 is an alanine, d-alanine, an arginine residue or absent,
• W18 is a leucine residue, a d-leucine residue, an alanine residue, a serine residue or absent,
• W19 is a lysine residue, a d-lysine residue, an alanine residue, a leucine residue, an isoleucine residue or absent,
• W20 is threonine, a d-threonine residue, an alanine residue leucine residue or absent,
• W21 is threonine, a d-threonine residue, an alanine residue a lysine residue or aspartic acid or absent,
• W22 is a valine, a d-valine residue, an alanine residue or absent,
• W23 is isoleucine residue, a d-isoleucine residue, an alanine residue a serine residue or absent,
• W24 is leucine residue, a d-leucine residue, an alanine residue an arginine residue or absent,
• W25 is a lysine residue, a d-lysine residue, an alanine residue or absent,
• W26 is a valine residue, a d-valine residue, an alanine residue or absent,
• W27 is a lysine residue, a d-lysine residue, an alanine residue or absent,
• W28 is a serine residue a d-serine residue, an alanine residue or absent,
• W29 is a glycine residue, a d-glycine residue, an alanine residue or absent,
• W30 is a threonine residue, a d-threonine residue, an alanine residue or absent,
• W31 is a leucine residue, a d-leucine residue, an alanine residue or absent,
• W32 is a lysine residue, a d-lysine residue, an alanine residue or absent,
• wherein when W20-W32 is absent at least one of W1-W23 is also absent and wherein when W1-W7 and W20-W32 is absent, at least one of W8-W19 is absent, a d-amino acid or alanine.

A compound represented by Formula D or a pharmaceutically acceptable salt thereof, wherein:

• T-L-Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10-Z11-Z12-Z13-Z14-Z15-Z16-Z17-Z18-Z19-Z20-Z21-Z22-Z23-Z24-Z25-Z26-Z27-Z28-Z29-Z30-Z31-Z32-Z33-Z34-Z35-Z36-Z37-Z38-Z39-Z40-Z41-Z42-Z43-Z44-Z45-Z46-Z47-R1;
• wherein:
• L is a linking moiety represented by C(O) and bonded to the N terminal nitrogen of Z1 or the next present amino acid residue if Z1 is absent;
• and T is a lipophilic tether moiety bonded to L;
• R1 is OR2 or N(R2)2, each R2 is independently H or alkyl, wherein at least three contiguous Z1-Z32 amino acid residues are present, and wherein
• Z1 is a glycine residue, a d-glycine residue, an alanine residue or absent,
• Z2 is an alanine residue a d-alanine residue or absent,
• Z3 is a lysine residue, a d-lysine residue, an alanine residue or absent,
• Z4 is a phenylalanine residue, a d-phenylalanine residue, an alanine residue or absent,
• Z5 is a lysine residue, a d-lysine residue, an alanine residue or absent,
• Z6 is a threonine residue, a d-threonine residue, an alanine residue or absent,
• Z7 is a serine residue a d-serine residue, an alanine residue or absent,
• Z8 is an alanine residue, a d-alanine residue or absent,
• Z9 is a glutamine residue, a d-glutamine residue, an alanine residue or absent,
• Z10 is a histidine residue, a d-histidine residue, an alanine residue or absent,
• Z11 is an alanine residue, a d-alanine residue or absent,
• Z12 is a leucine residue, a d-leucine residue, an alanine residue or absent,
• Z13 is a threonine residue, a d-threonine residue, an alanine residue or absent,
• Z14 is a serine residue, a d-serine residue, an alanine residue or absent;
• Z15 is a valine residue, a d-valine residue, an alanine residue or absent,
• Z16 is a serine residue, a d-serine residue, an alanine residue or absent,
• Z17 is an arginine residue, a d-arginine residue, an alanine residue or absent,
• Z18 is a glycine residue, a d-glycine residue, an alanine residue or absent,
• Z19 is a serine residue, a d-serine residue, an alanine residue or absent,
• Z20 is a serine residue, a d-serine residue, an alanine residue absent,
• Z21 is a leucine residue, a d-leucine residue, an alanine residue or absent,
• Z22 is a lysine residue, a d-lysine residue, an alanine residue or absent,
• Z23 is a isoleucine residue, a d-isoleucine residue, an alanine residue a serine residue or absent,
• Z24 is a leucine residue, a d-leucine residue, an alanine residue or absent,
• Z25 is a serine residue, a d-serine residue, an alanine residue or absent,
• Z26 is a lysine residue, a d-lysine residue, an alanine residue or absent,
• Z27 is glycine residue, a d-glycine residue, an alanine residue or absent,
• Z28 is a lysine residue, a d-lysine residue, an alanine residue or absent,
• Z29 is an arginine residue, a d-arginine residue, an alanine residue or absent,
• Z30 is a glycine residue, a d-glycine residue, an alanine residue or absent,
• Z31 is a glycine residue, a d-glycine residue, an alanine residue or absent,
• Z32 is a histidine residue, a d-histidine residue, an alanine residue or absent,
• Z33 is a serine residue, a d-serine residue, an alanine residue or absent,
• Z34 is a serine residue, a d-serine residue, an alanine residue cysteine, or absent,
• Z35 is a valine residue, a d-valine residue, an alanine residue a phenylalanine residue, or absent,
• Z36 is a serine residue, a d-serine residue, an alanine residue a histidine residue or absent,
• Z37 is a threonine residue, a d-threonine residue, an alanine residue or absent,
• Z38 is a glutamic acid residue, a d-glutamic acid residue, an alanine residue or absent,
• Z39 is a serine residue, a d-serine residue, an alanine residue or absent,
• Z40 is a glutamic acid, a d-glutaminc acid residue, an alanine residue or absent
• Z41 is a serine residue, a d-serine residue, an alanine residue or absent,
• Z42 is a serine residue, a d-serine residue, an alanine residue or absent,
• Z43 is a serine residue, a d-serine residue, an alanine residue or absent,
• Z44 is a phenylalanine residue, a d-phenylalanine residue, an alanine residue or absent,
• Z45 is a histidine residue, a d-histidine residue, an alanine residue or absent,
• Z46 is a serine residue, a d-serine residue, an alanine residue or absent,
• Z47 is a serine residue, a d-serine residue, an alanine residue or absent, wherein at least one of Z1-Z47 is absent.

A compound represented by Formula I:

• T-L-P,
• or a pharmaceutically acceptable salt thereof, wherein;
• P is a peptide sequence selected from:
• SEQ ID NOS:
• 1-368;
• L is a linking moiety represented by C(O) and bonded to P at an N terminal nitrogen of an N-terminal amino-acid residue;
• and T is a lipophilic tether moiety bonded to L.