Method for determination of progression risk of glaucoma

A method of determining the presence or the absence of a glaucoma risk, comprising the steps of:

• detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs:
• 203 to 752 or a complementary sequence thereto (step A), and
• comparing the allele and/or the genotype detected in said step A with at least one of an allele and/or a genotype, comprising a high-risk allele, in the base sequences shown in SEQ ID NOs:
• 203 to 752 (step B),
• wherein the presence of a glaucoma risk is determined in a case where the allele detected in said step A is the high-risk allele, or
• wherein the presence of a glaucoma risk is determined in a case where the genotype detected in said step A is a homozygote of the genotype comprising the high-risk allele or a heterozygote when the high-risk allele complies with a dominant genetic model, or
• wherein the presence of a glaucoma risk is determined in a case where the genotype detected in said step A is a homozygote of the genotype comprising the high-risk allele when the high-risk allele complies with a recessive genetic model.