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US 2013/0210650 A1Published application
Peripheral gene expression biomarkers for autism
AssigneeThe Regents of the University of California
InventorsDaniel H. Geschwind, Yuhei Nishimura
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Abstract
The disclosed invention comprises methods and materials for screening cells for genetic profiles associated with autism spectrum disorders. The methods typically involve isolating a cell from an individual and then observing the expression profile of one or more genes in the cell, wherein certain expression patterns of the genes observed are associated with autism spectrum disorders.
Claims20
A kit comprising:
- a container;
- a primer composition contained within said container, wherein the primer composition includes a polymerase chain reaction (PCR) primer effective in the quantitative real time analysis of the mRNA expression levels of one or more genes selected from the group consisting of SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, and SEQ ID NO:
- 16;
- and
- a pharmaceutically-acceptable buffer composition.
11 more elements
A method of identifying a test mammalian cell having a gene expression profile observed in individuals diagnosed with autism comprising:
- observing an expression profile of at least one gene selected from the group consisting of SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, and SEQ ID NO:
- 16 in the test mammalian cell;
- wherein:
- an expression profile of a gene in the group that is at least two standard deviations from a mean expression profile of the gene in a control mammalian cell obtained from an individual not affected with autism identifies the test mammalian cell as having a gene expression profile observed in individuals diagnosed with autism;
- and
- the test mammalian cell is obtained from an individual where at least one evaluation is performed from a diagnostic procedure for autism.
12 more elements
Dependencies are inferred from the claim text.