Multifunctional nanoplatforms for fluorescence imaging and photodynamic therapy developed by post-loading photosensitizer and fluorophore to polyacrylamide nanoparticles
AssigneesHealth Research, Inc., The Regents of the University of Michigan, The Research Foundation of State University of New York
InventorsRavindra K. Pandey, Raoul Kopelman, Anurag Gupta, Munawwar Sajjad
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Abstract
A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and a postloaded imaging agent and methods for making and using same.
Claims21
A composition comprising PAA nanoparticles containing a tetrapyrollic photosensitizer for Photodynamic therapy and an imaging agent for fluorescent imaging.
A method for imaging comprising:
- injecting PAA nanoparticles containing post loaded photosensitizer into a subject,
- injecting an imaging agent, and
- imaging the subject at 24, 48 and 72 h post injections.
A method for making PAA nanoparticle's containing a photosensitizer and an imaging agent by post loading a photosensitizer and a fluorophore onto a preprepared PAA nanoparticle.
A method for making PAA nanoparticle's by conjugating a fluorophore to a PAA nanoparticle and then postloading a photosensitizer to the PAA nanoparticle.
A composition comprising a mixture of different PAA nanoparticles, at least one of which contains a postloaded photosensitizer and at least one of which contains a postloaded cyanine dye.
Dependencies are inferred from the claim text.