Analyte sensor
AssigneeEdwards Lifesciences Corporation
InventorJames R. Petisee
Life of this patent
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Abstract
The present disclosure relates generally to an electrochemical sensor comprising a membrane layer comprising one or both of an active enzymatic portion and an inactive-enzymatic or non-enzymatic portion, at least one electrode disposed beneath the membrane and either at least one pH sensor or a hematocrit sensor. The present disclosure also relates to methods of adjusting analyte concentration values using a correction factor based on measured pH values and/or measured hematocrit levels.
Claims26
An analyte sensor comprising:
- a membrane comprising an active enzymatic portion and an inactive-enzymatic or non-enzymatic portion;
- at least two electrodes disposed beneath the membrane;
- and
- a hematocrit sensor positioned in proximity to the at least two electrodes.
The sensor of any one of the previous claims, wherein the at least two electrodes comprises a working electrode and a blank electrode, and the membrane is partitioned over the working electrode and the blank electrode.
An analyte sensor comprising
- a substrate having a first surface and a second surface;
- at least one electrode disposed on the first surface and a hematocrit sensor disposed on the second surface, wherein the at least one electrode is disposed beneath a membrane, the membrane comprising an active enzymatic portion and an inactive-enzymatic or non-enzymatic portion.
The sensor of claim 11, wherein the hematocrit sensor comprises at least two electrodes.
The sensor of claim 13, wherein the membrane is partitioned over the working electrode associated with the active enzymatic portion and the blank electrode associated with the inactive-enzymatic or non-enzymatic portion.
An analyte sensor comprising:
- a membrane comprising an active enzymatic portion and an inactive-enzymatic or non-enzymatic portion;
- at least one electrode disposed beneath the membrane;
- and
- a hematocrit sensor comprising at least one optical fiber positioned in proximity to the at least two electrodes disposed beneath the membrane.
An analyte sensor comprising
- a membrane comprising an active enzymatic portion and an inactive-enzymatic or non-enzymatic portion;
- at least two electrodes disposed beneath the membrane;
- and
- a hematocrit sensor disposed beneath the membrane and in proximity to the at least two electrodes.
A method comprising:
- providing an analyte sensor comprising:
- a membrane layer comprising one or both of an active enzymatic portion and an inactive-enzymatic or non-enzymatic portion;
- at least one working electrode disposed beneath one or both of the active enzymatic portion of the membrane and the inactive-enzymatic or non-enzymatic portion of the membrane;
- and
- a hematocrit sensor positioned in proximity to one or both of the at least one working electrode;
- obtaining a first signal generated by the at least one electrode for determining a concentration of an analyte when in contact with an intravenous sample and providing an analyte concentration value based on the first signal;
- obtaining a second signal generated by the hematocrit sensor corresponding to a hematocrit level of the intravenous sample;
- providing a correction factor based on the second signal;
- and
- adjusting the analyte concentration value using the correction factor.
Dependencies are inferred from the claim text.