Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders
AssigneeAbbott Laboratories
InventorHarry A. Dugger, III
Life of this patent
Estimating the term…
Abstract
Buccal aerosol sprays or capsules using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation I: aqueous polar solvent, active compound, and optional flavoring agent; formulation II: aqueous polar solvent, active compound, optionally flavoring agent, and propellant; formulation III: non-polar solvent, active compound, and optional flavoring agent; and formulation IV: non-polar solvent, active compound, optional flavoring agent, and propellant.
Claims13
1-111. (canceled)
A propellant free buccal spray composition for transmucosal administration of an active compound comprising:
- (a) meloxicam or a pharmaceutically acceptable salt thereof in an amount of between about 0.001 and about 60 percent by weight of the total composition;
- and
- (b) a polar solvent in an amount of about 5 to about 30 percent by weight of the total composition.
A pump spray container comprising:
- a pump spray formulation comprising a propellant free buccal spray composition for transmucosal administration of an active compound comprising:
- (a) meloxicam or a pharmaceutically acceptable salt thereof;
- and
- (b) a polar solvent.
Dependencies are inferred from the claim text.