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US 2013/0196965 A1Published application
Cyclic amides
AssigneeHoffmann-La Roche Inc.
InventorsLilli Anselm, David Banner, Jean-Baptiste Blanc, Delphine Gaufreteau, Wolfgang Haap, Guido Hartmann, Bernd Kuhn, Thomas Luebbers, Jens-Uwe Peters, Beat Spinnler
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Abstract
The invention relates to a compound of formula (I) wherein A, B, D and R1 to R6 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
Claims16
A compound of formula (I)
- wherein
- A is —O—, —S—, —CH2—, —NH— or —SO2—;
- B is a five to twelve membered carbocyclic ring or a five to twelve membered heterocyclic ring, wherein the ring is optionally substituted with one or two substituents independently selected from halogen, alkyl, alkoxy, haloalkyl, haloalkoxy, cycloalkyl, cycloalkylalkoxy, sulfonyl, sulfanyl, cycloalkylsulfonyl, cycloalkylsulfanyl, alkoxycarbonylazetidinyl, cyano, azetidinyl or alkylsulfanyl;
- D is —O—, —S—, —CH2—, —NH— or —SO2—;
- one of R1, R2, R3 and R4 is hydrogen and the other ones are independently selected from hydrogen, halogen, alkyl, alkoxy, haloalkoxy, cycloalkyl and phenyl;
- R5 and R6 are independently selected from and hydrogen, alkyl, haloalkyl, cycloalkyl, phenyl and phenylalkyl;
- or R5 and R6 together with the carbon atom to which they are attached form cycloalkyl, pyrrolidinyl or piperidinyl;
- and
- is a carbon-carbon single bond or a carbon-carbon double bond;
- or a pharmaceutically acceptable salt or ester thereof.
7 more elements
Dependencies are inferred from the claim text.