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US 2013/0189679 A1Published application
Pseudogenes and uses thereof
AssigneeThe Regents of the University of Michigan
InventorsArul M. Chinnaiyan, Chandan Kumar-Sinha, Shanker Kalyana-Sundaram
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Abstract
The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to pseudogenes as diagnostic markers and clinical targets for prostate cancer.
Claims20
A method of screening for the presence of breast cancer in a subject, comprising
- (a) contacting a biological sample from a subject with a reagent for detecting the level of expression of ATPase, aminophospholipid transporter, class I, type 8A, member 2 pseudogene (ATP8A2-Ψ);
- and
- (b) detecting the level of expression of said ATP8A2-Ψ in said sample using an in vitro assay,
- wherein an increased level of expression of said ATP8A2-Ψ in said sample relative to the level in normal breast cells is indicative of breast cancer in said subject.
1 more element
A method of screening for the presence of prostate cancer in a subject, comprising
- (a) contacting a biological sample from a subject with a reagent for detecting the level of expression of coxsackie virus and adenovirus receptor pseudogene (CXADR-Ψ);
- and
- (b) detecting the level of expression of said CXADR-Ψ in said sample using an in vitro assay,
- wherein an increased level of expression of said CXADR-Ψ in said sample relative to the level in normal prostate cells is indicative of prostate cancer in said subject.
1 more element
A method of screening for the presence of prostate cancer in a subject, comprising
- (a) contacting a biological sample from a subject with a reagent for detecting the presence of a kallikrein-related peptidase 4-kallikrein pseudogene 1 (KLK4-KLKP1) gene fusion;
- and
- (b) detecting the presence or absence of said KLK4-KLKP1 gene fusion in said sample using an in vitro assay,
- wherein the presence of said KLK4-KLKP1 gene fusion in said sample is indicative of prostate cancer in said subject.
1 more element
Dependencies are inferred from the claim text.