Endophytic Fungi from Pteromischum SP. Plant, Compounds and Methods of Use
AssigneeThe Regents of the University of California
InventorsGary A. Strobel, Yuhao Ren, David B. Teplow
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Abstract
The present disclosure relates to endophytic fungi from higher plants such as a Pteromischum sp. plant, and to extracts and compounds from such fungi that have desirable biological activities, such as antifungal and immunosuppressive activities. The present disclosure further relates to compositions comprising such extracts and compounds, as well as methods of making and using the compositions.
Claims21
(canceled)
The method according to claim 11, wherein the endophytic fungi is a Colletotrichum sp.
The method according to claim 11, wherein the fungus has biological activity against a fungal plant pathogen.
5-8. (canceled)
The method according to claim 11, wherein the compound has a molecular mass of 1081.7, 1095.7, 1111.7 or 1127.7.
The method according to claim 11, wherein the compound includes a tetrapeptide sequence Val-Ile-Ser-Ile (SEQ ID NO:
- 1).
A method of suppressing an immune response, comprising:
- administering to a subject in need of immunosuppression a therapeutically effective amount of a composition comprising an endophytic fungus isolated from a Pteromischum sp. plant, wherein the isolated endophytic fungus has antifungal or immunosuppressive activity, a crude extract of the endophytic fungus or a compound obtained from the endophytic fungus, thereby suppressing the immune response.
A method to protect a plant against a fungal pathogen comprising treating the plant with an effective amount of a composition comprising an endophytic fungus isolated from a Pteromischum sp. plant, wherein the isolated endophytic fungus has antifungal or immunosuppressive activity, a crude extract of the endophytic fungus or a compound obtained from the endophytic fungus, thereby protecting the plant against the fungal pathogen.
A method of treating a subject which comprises
- administering to the subject a peptide obtained from Colletotrichum dematium, wherein the peptide has a molecular mass of about 1127.7 Da and contains residues of Ile, Val, Ser, N-methyl-Val and beta-aminoisobutryic acid in nominal molar ratios of 3:2:1:1:1, respectively, and a tetrapeptide sequence Val-Ile-Ser-Ile (SEQ ID NO:1).
Dependencies are inferred from the claim text.