Antibodies for the treatment of hiv
OwnerChristine Klinguer-Hamourinventor
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Abstract
The present invention relates to isolated antibodies, or the derivatives or antigen binding fragments of same, capable of binding to CXCR4 but also of inducing conformational change of the CXCR4 homodimers and able to inhibit HIV-1 primary isolate replication in PBMC. More particularly, the present invention relates to the 515H7 and 301 aE5 monoclonal antibodies, specific to the CXCR4 protein, as well as their use for the treatment of HIV infection. Pharmaceutical compositions comprising such antibodies and a process for the selection of such antibodies are also covered.
Claims32
An isolated antibody, or one of its antigen binding fragments or derivatives, wherein it comprises at least one complementary determining region CDR chosen from CDRs comprising the amino acid sequences SEQ ID Nos. 1 to 6 and 30 to 33 as defined by the IMGT numbering system.
Dependencies are inferred from the claim text.