Model Animal for Studying Hair Growth Cycle
OwnerToru Imamura, Miho Ueki +1inventors
InventorsToru Imamura, Miho Ueki, Yuko Oda
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Abstract
The present invention prepared a non-human animal in which Fgf18 gene was knocked out in a keratin-5 positive cell-specific manner using a Cre-loxP system; it provides a non-human model animal in which FGF18 expression has been inhibited in a hair follicle-specific manner to shorten the telogen phase of hair growth cycle. The non-human model animal is useful in studying hair follicles and skin, particularly hair growth occurring cyclically in hair follicle cells, and is applicable to the development of and screening for novel drugs against hair follicle or skin disorders.
Claims7
A non-human model animal in which the expression of FGF18 is inhibited or suppressed in a hair follicle-specific manner to shorten the telogen phase of haft growth cycle, wherein at least one of a pair of fibroblast growth factor 18 (Fgf18) alleles has been knocked out or knocked down in a keratin 5-positive cell-specific manner.
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