Methods and apparatus related to gate boundaries within a data space

One or more non-transitory processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to:

• receive a set of parameter values defining a boundary within a data space associated with a dataset, the dataset representing signaling related to a test substance;
• define a first metric based on a first portion of the dataset associated with a first region defined by the boundary;
• modify the boundary;
• and
• define a second metric based on a second portion of the dataset associated with a second region defined by the boundary after the boundary is modified, the second region being different than the first region.

One or more non-transitory processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to:

• receive a set of parameter values defining a first boundary within a data space associated with a dataset, the first boundary defining a region inside the first boundary, the dataset representing signaling related to a test substance;
• receive a set of parameter values defining a second boundary circumscribing the first boundary, the second boundary being within the data space;
• and
• define a plurality of metrics based on a portion of the dataset included in the region and based on a plurality of relationships between a plurality of perturbations of the second boundary and a portion of the dataset outside of the region.