Medical device with coating that promotes endothelial cell adherence and differentiation

(canceled)

A method for coating a medical device for implantation comprising the steps of:

• a. applying at least one layer of a biocompatible coating matrix to the surface of the medical device, wherein the biocompatible matrix comprises at least one component layer selected from the group consisting of a polyurethane, a segmented polyurethane-urea/heparin, a poly-L-lactic acid, a cellulose ester, a polyethylene glycol, a polyvinyl acetate, a dextran, gelatin, collagen, elastin, laminin, fibronectin, vitronectin, heparin, fibrin, cellulose and carbon and fullerene, and
• b. applying to the biocompatible matrix, simultaneously or sequentially, a therapeutically effective amounts of at least one type of antibody, antibody fragment or a combination thereof to stimulates endothelial cell growth and differentiation.

(canceled)

A method for inhibiting deposition of thrombotic material on an implantable medical device that has been implanted in a patient in need thereof, comprising:

• providing a coating matrix on a medical device for implantation comprising the steps of:
• a. coating the implantable medical device or a portion thereof with a therapeutically effective matrix layer comprising one or more molecules and at least one molecule is capable of binding an antigen on the surface of an endothelial cell or a progenitor endothelial cell, and
• b. implanting said therapeutically coated medical device in a patient in need thereof.