Crosslinked hydrogels and methods of making and using thereof
AssigneeUniversity of Utah Research Foundation
InventorsGlenn D. Prestwich, Aleksander Skardal, Jianxing Zhang
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Abstract
Described herein are modified gelatins or the pharmaceutically-acceptable salts or esters thereof comprising at least one actinically crosslinkable group covalently bonded to gelatin. The modified gelatins are useful in producing composites that ultimately can be used to produce three-dimensional engineered biological constructs. The composites are the polymerization product between the modified gelatin and at least one actinically crosslinkable macromolecule. Methods for making the modified gelatins are also described herein.
Claims31
A modified gelatin or the pharmaceutically-acceptable salt or ester thereof, wherein the modified gelatin comprises a residue of formula I
- wherein
- Z is a residue of gelatin;
- X1 and X2 are, independently, oxygen or a substituted or unsubstituted amino group;
- Y is an actinically crosslinkable group;
- n is from 1 to 10;
- and
- o is from 1 to 100.
A modified gelatin produced by the process comprising
- (a) converting at least one carboxyl group present in gelatin to a hydroxyl group or amino group to produce a hydroxylated gelatin and/or aminated gelatin;
- and
- (b) reacting the hydroxylated gelatin and/or aminated gelatin with an agent comprising an actinically crosslinkable group, wherein the agent reacts with the hydroxylated gelatin and/or aminated gelatin to produce a covalent bond.
A three-dimensional engineered biological construct produced by the method of claim 24.
A modified gelatin, wherein the modified gelatin comprises a residue of formula II
- wherein
- Z is a residue of gelatin;
- X1 and X2 are, independently, oxygen or a substituted or unsubstituted amino group;
- n is from 1 to 10;
- and
- o is from 1 to 100.
Dependencies are inferred from the claim text.