Back to results
US 2013/0172618 A1Published application
Process for the preparation of 4-iodo-3-nitrobenzamide
AssigneeDivi's Laboratories, Ltd.
InventorsMurali Krishna Prasad Divi, Mysore Aswatha Narayana Rao, Venkataramana Rajuri
Life of this patent
Estimating the term…
Abstract
A process for the preparation of 4-iodo-3-nitrobenzamide free from the impurities formed due to nucleophilic substitution of the labile iodo group is disclosed.
Claims5
A process for the preparation of 4-iodo-3-nitrobenzamide (Iniparib), which comprises:
- a) converting 4-iodo-3-nitrobenzoic acid to its methyl ester,
- b) reacting the methyl ester with ammonia to give 4-iodo-3-nitrobenzamide, and
- c) crystallization of 4-iodo-3-nitrobenzamide using a mixture of alcohol and water.
Dependencies are inferred from the claim text.