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US 2013/0172587 A1Published application
Process for the Preparation of Fluticasone Propionate
AssigneeGenerics [UK] Limited
InventorsVinayak G. Gore, Mahesh Gadakar, K. Pokharkar, V. Wakchure
Life of this patent
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Abstract
The present invention relates to a process for the preparation of steroidal 17β-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17β-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.
Claims26
1-8. (canceled)
A process of purifying a compound II
- wherein X is a leaving group, comprising crystallising compound II using a solvent system comprising a polar and a non-polar solvent.
10-21. (canceled)
A compound II
- wherein X is a leaving group, which has an HPLC purity of greater than 95%, or greater than 97%, or greater than 98%, or greater than 99%, or greater than 99.5%.
Dependencies are inferred from the claim text.