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US 2013/0172564 A1Published application
Phenol derivatives and pharmaceutical or cosmetic use thereof
AssigneeGalderma Research & Development
InventorsCédric Poinsard, Pascal Collette, Jean-Michel Rethore
Life of this patent
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Abstract
The use of compounds in the treatment of skin disorders is described. In particular, use of a compound of formula (I): or one of its pharmaceutically acceptable salts, solvates or hydrates in the preparation of a medicament to treat skin pathologies is described.
Claims16
A compound of formula (I):
- in which:
- R1 represents a C1-6 alkyl, C3-7 cycloalkyl, C1-6 alkyloxy, —S(O)m—C1-6 alkyl, C1-6 fluoroalkyl, C1-6 fluoroalkyloxy, —(CH2)n—C3-9 cycloalkyl, —(CH2)n—C3-9 cycloalkyl, C2-6 alkyl-OH, —(CH2)n—C1-6 alkyloxy, —(CH2)n—C1-6 fluoroalkyl, —(CH2)p—O—C1-6 fluoroalkyl, CORa, CN, NO2 or NR8R9 group, a halogen or a phenyl or heteroaryl group comprising either a) from 1 to 4 nitrogen atoms or b) an oxygen or sulphur atom and 1 or 2 nitrogen atom(s);
- wherein the phenyl and heteroaryl groups can optionally be substituted with one to three identical or different Rb groups,
- R2 represents a C1-6 alkyl, C3-7 cycloalkyl, C1-6 alkyloxy, —S(O)vC1-6 alkyl, C1-6 fluoroalkyl, C1-6 fluoroalkyloxy, —(CH2)q—C3-9 cycloalkyl, —(CH2)q—C3-9 cycloalkyl, C2-6 alkyl-OH, —(CH2)q—C1-6 alkyloxy, —(CH2)q—C1-6 fluoroalkyl, —(CH2)r—O—C1-6 fluoroalkyl, CORd, CN, NO2 or NR8′R9′ group, a hydrogen atom, a halogen or a phenyl or heteroaryl group comprising either a) from 1 to 4 nitrogen atoms or b) an oxygen or sulphur atom and 1 or 2 nitrogen atom(s);
- wherein the phenyl and heteroaryl groups can optionally be substituted with one to three identical or different Re groups,
- R3 represents a hydrogen atom or a C1-9 alkyl, C3-9 cycloalkyl, C1-6 fluoroalkyl, —(CH2)t—C3-9 cycloalkyl, —C2-6 alkyl-OH, —(CH2)—C1-6 alkyloxy, —(CH2)t—C3-7 cycloalkyl, —(CH2)t—C1-6 fluoroalkyl, or —(CH2)u—O—C1-6 fluoroalkyl group,
- R4, R5, R6 and R7 are identical or different and represent either a hydrogen atom or a C1-6 alkyl, C3-7 cycloalkyl, C1-6 alkyloxy, —S(O)t—C1-6 alkyl, C1-6 fluoroalkyl, C1-6 fluoroalkyloxy, —(CH2)i—C3-9 cycloalkyl, —(CH2)i—C3-9 cycloalkyl, —C1-6 alkyl-OH, —(CH2)i—C1-6 alkyloxy, —(CH2)i—C1-6 fluoroalkyl, —(CH2)j—O—C1-6 fluoroalkyl, CORa, CN or NR10R11 group, or a halogen or a phenyl or heteroaryl group comprising either a) from 1 to 4 nitrogen atoms or b) an oxygen or sulphur atom and 1 or 2 nitrogen atom(s) wherein the phenyl and heteroaryl groups can optionally be substituted with one to three identical or different Rc groups,
- Ra, Rd and Rf are identical or different and represent a C1-6 alkyl, C1-6 alkyloxy or NR12R13 group,
- Rb, Rc and Re are identical or different and represent a halogen, or a C1-6 alkyl, C3-7 cycloalkyl, C1-6 alkyloxy, —S(O)k—C1-6 alkyl, C1-6 fluoroalkyl, C1-6 fluoroalkyloxy, —(CH2)g—C3-7 cycloalkyl, OH, —(CH2)g—C3-7 cycloalkyl, C1-6 alkyl-OH, —(CH2)g—C1-6 alkyloxy, —(CH2)g—C1-6 fluoroalkyl, —(CH2)w—O—C1-6 fluoroalkyl, CORf, CN or NR14R15 group,
- R8, R8′, R9, R9′, R10, R11, R12, R13, R14 and R15 are identical or different and represent a hydrogen atom, or a C1-6 alkyl, C3-7 cycloalkyl, —(CH2)h—C3-7 cycloalkyl or —(CH2)h—C1-6 fluoroalkyl group;
- optionally, the R8 and R9 groups can form, with the nitrogen atom which bears them, a heterocycle;
- optionally, the R8′ and R9′ groups can form, with the nitrogen atom which bears them, a heterocycle;
- optionally, the R10 and R11 groups can form, with the nitrogen atom which bears them, a heterocycle;
- optionally, the R12 and R13 groups can form, with the nitrogen atom which bears them, a heterocycle;
- optionally, the R14 and R15 groups can form, with the nitrogen atom which bears them, a heterocycle;
- g, h, i, n, q and t are different or identical and are equal to 1, 2 or 3,
- k, l, m and v are different or identical and are equal to 0, 1 or 2,
- j, p, r, u and w are different or identical and are equal to 2, 3 or 4,
- and also a pharmaceutically acceptable salt, solvate, hydrate, conformer or rotamer thereof.
16 more elements
Dependencies are inferred from the claim text.