US 2013/0172562 A1 · PROCESS FOR THE PREPARATION OF A SINGLE ENANTIOMER OF 3-AMINOPIPERIDINE DIHYDROCHLORIDE

Abstract

A process comprising: (a) reduction of N-acetyl-3-aminopyridine (2): or its salt in the presence of hydrogen and a palladium catalyst deposited on solid support; (b) converting racemic N-acetyl-3-aminopiperidine (3) or its salt produced in step (a) to rac-3-aminopiperidine (rac-4) or its salt; (c) resolution of the racemic 3-aminopiperidine (rac-4) or its salt produced in step (b) with a chiral acid.

Claims17

Dependent claims

A process comprising:

(a) reduction of N-acetyl-3-aminopyridine (2):
or its salt in the presence of hydrogen and a palladium catalyst deposited on solid support;
(b) converting racemic N-acetyl-3-aminopiperidine (3) or its salt produced in step (a) to rac-3-aminopiperidine (rac-4) or its salt;
(c) resolution of the racemic 3-aminopiperidine (rac-4) or its salt produced in step (b) with a chiral acid

1 more element

Dependencies are inferred from the claim text.

Facts

Application

13/704,142Filed 17 Jun 2011

Priority

17 Jun 2010

Published

4 Jul 2013

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

C07D 211/02
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings: preparation by ring-closure or hydrogenation
B01J 21/18
Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium: carbon
B01J 23/44
Of the platinum group metals: palladium
C07B 57/00
Separation of optically-active compounds

Process for the preparation of a single enantiomer of 3-aminopiperidine dihydrochloride

Life of this patent

Process for the preparation of a single enantiomer of 3-aminopiperidine dihydrochloride

Life of this patent

Abstract

Claims17