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US 2013/0172560 A1Published application
Processes for making cyclopropyl amide derivatives and intermediates associated therewith
AssigneeAstraZeneca AB
InventorRobert Stranne
Life of this patent
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Abstract
Presented herein are processes for making cyclopropyl amide derivatives of formula I, and/or pharmaceutically acceptable salts thereof, and intermediates associated therewith. At least one cyclopropyl amide derivative of formula I, or pharmaceutically acceptable salt thereof is useful to treat at least one histamine H3 receptor associated condition.
Claims23
A compound of formula Ia, or a pharmaceutically acceptable salt thereof:
A process for preparing a compound of formula Ib, or a pharmaceutically acceptable salt thereof:
- wherein:
- the process comprises reacting a compound of formula Ia:
- with an activating agent, and then reacting the resulting mixture with a compound of formula IVa, or a suitable salt thereof:
A process for preparing a compound of formula Ic, or a pharmaceutically acceptable salt thereof:
- wherein:
- the process comprises reacting a compound of formula Ia:
- with an activating agent and then reacting the resulting mixture with a compound of formula IVb, or a suitable salt thereof:
- and a base.
1 more element
Dependencies are inferred from the claim text.