Heteroaryl amide derivatives

A compound of the formula:

• or a pharmaceutically acceptable salt or hydrate thereof, wherein:
• T, U and V are independently chosen from CR3, CRA and N, such that exactly one of T, U and V is CRA;
• W is —C(═O)NR4—, —NR4C(═O)— or —NR4—NR4—C(═O)—;
• X is absent or C1-C6alkylene that is substituted with from 0 to 4 substituents independently chosen from:
• (i) C1-C4alkyl, (C3-C8cycloalkyl)C0-C2alkyl, (4- to 10-membered heterocycle)C0-C1alkyl, and phenylC0-C2alkyl;
• (ii) substituents that taken together with the atom to which they are attached or with the atoms through which they are connected form a 3- to 8-membered cycloalkyl or heterocycloalkyl ring;
• and
• (iii) a substituent that taken together with R4 and the atoms through which they are connected forms a 4- to 7-membered heterocycloalkyl;
• Y is C3-C16cycloalkyl, 4- to 16-membered heterocycloalkyl, 6- to 16-membered aryl or 5- to 16-membered heteroaryl, each of which is substituted with from 0 to 6 substituents independently chosen from hydroxy, halogen, cyano, amino, nitro, oxo, aminocarbonyl, aminosulfonyl, COOH, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6haloalkyl, C1-C6hydroxyalkl, C1-C6aminoalkyl, C1-C6alkoxy C1-C6haloalkoxy, C2-C6alkyl ether, C1-C6alkanoyl, C1-C6alkylsulfonyl, C3-C7cycloalkyl)C0-C4alkyl, mono- or di-(C1-C6alkyl)amino, C1-C6alkanoylamino, mono- or di-(C1-C6alkyl)aminocarbonyl, mono- or di-(C1-C6alkyl)aminosulfonyl and (C1-C6alkyl)sulfonylamino;
• Z1 and Z3 are independently N or CR2;
• Z2 is N, CR2 or CRA;
• Each R2 and each R3 is independently chosen from hydrogen, halogen, cyano, amino, nitro, aminocarbonyl, aminosulfonyl, COOH, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6haloalkyl, C1-C6hydroxyalkyl, C1-C6aminoalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkanoyl, C2-C6alkyl ether, (C3-C7cycloalkyl)C0-C4alkyl, mono- or di-(C1-C6alkyl)amino, C1-C6alkylsulfonyl, C1-C6alkanoylamino, mono- or di-(C1-C6alkyl)aminocarbonyl, mono- or di-(C1-C6alkyl)aminosulfonyl and (C1-C6alkyl)sulfonylamino;
• Each R4 is independently hydrogen, C1-C6alkyl, or (C3-C8cycloalkyl)C0-C2alkyl, or R4 taken together with a substituent of X and the atoms through which they are connected forms a 4- to 7-membered heterocycloalkyl;
• RA is a group of the formula -L-A,
• or a group chosen from M, such that RA is not absent, wherein:
• L is absent or C1-C6alkylene that is optionally modified by the replacement of a carbon-carbon single bond with a double or triple carbon-carbon bond, and which alkylene is optionally substituted with oxo;
• and
• A is absent or CO, O, NR6, S, SO, SO2, CONR6, NR6CO, (C4-C12cycloalkyl), (4 to 7-membered heterocycle), phenyl-E-, or (5- or 6-membered heterocycle)-E-;
• wherein R6 is hydrogen or C1-C6alkyl and E is O, S, SO2 or NH;
• such that each -L-A is substituted with from 1 to 6 groups independently chosen from M;
• and
• each M is;
• (i) hydroxy, halogen, cyano, amino, imino, hydroxyimino, aminocarbonyl, aminosulfonyl or COOH;
• (ii) C1-C6haloalkyl, C1-C6alkoxy, C1-C6alkylthio, (3- to 12-membered carbocycle)C0-C4alkyl, (4- to 10-membered heterocycle)C0-C4alkyl, C2-C6alkyl ether, C1-C6alkanoyl, C1-C6alkanoyloxy, C1-C6alkanoylamino, C1-C6alkylsulfonyl, C1-C6alkylsulfonylC0-C4alkyl, C1-C6alkylsulfonylamino, C1-C6alkylsulfonylaminoC0-C4alkyl, C1-C6alkylsulfonyloxy, mono- or di-(C1-C6alkyl)aminoC0-C4alkyl, mono- or di-(C1-C6alkyl)aminosulfonyl, mono- or di-(C1-C6alkyl)aminocarbonylC0-C1alkyl or C1-C6alkylsilyloxy;
• each of which is substituted with from 0 to 6 substituents independently chosen from oxo, amino, halogen, hydroxy, cyano, aminocarbonyl, aminosulfonyl, COOH, C1-C6alkyl optionally substituted with COOH, amino, cyano, C1-C6alkoxycarbonyl or C1-C6alkoxy, C1-C6hydroxyalkyl, C1-C6haloalkyl, imino, hydroxyimino, C1-C6alkoxy that is optionally substituted with C1-C6alkanoyloxy, C1-C6haloalkoxy, C1-C6alkoxy, C2-C6alkyl ether, C1-C6alkanoyl, C1-C6alkanoyloxy, C1-C6alkylcarbonyl, C1-C6alkanoylamino, mono- or di-(C1-C6alkyl)amino, C1-C6alkylsulfonyl, C1-C6alkylsulfonylamino, mono- or di-(C1-C6alkyl)aminosulfonyl, mono- or di-(C1-C6alkylamino)carbonyl, phenyl optionally substituted with halogen or C1-C6haloalkyl, cycloalkyl, and 4- to 7-membered heterocycle;
• or
• (iii) two M taken together with the atoms through which they are connected form a bridge of the Formula —(CH2)q—P—(CH2)r—, wherein and r are independently 0 or 1 and P is CH2, O, NH or S, the bridge optionally substituted with from 0 to 2 substituents independently chosen from oxo and C1-C4alkyl;
• or
• (iv) when -L-A- is substituted by at least two M at the same atom of -L-A-, two M taken together with the atom to which they are attached form a 3- to 7-membered carbocyclic or heterocycloalkyl ring that is substituted with from 0 to 2 substituents independently chosen from oxo and C1-C4alkyl;
• such that:
• (i) RA is not C1-C6alkoxy:
• (ii) RA is a group of the formula -L-A and L is not absent if a group represented by M is aromatic and Y is aromatic or a 6-membered heterocycloalkyl;
• and (iii) if Y is optionally substituted phenyl, then RA is not C1-C4alkoxycarbonyl;
• o is an integer ranging from 0 to 4;
• p is 0 or 1;
• and
• R11 and R12 are:
• (i) independently chosen from:
• (a) hydrogen,
• (b) C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6haloalkyl, C2-C6alkyl ether, (C3-C7cycloalkyl)C0-C4alkyl, and phenylC0-C2alkyl, each of which is substituted with from 0 to 4 substituents independently chosen from hydroxy, halogen, cyano, amino, aminocarbonyl, aminosulfonyl, COOH, oxo, C1-C6alkyl, C1-C6haloalkyl, C1-C6hydroxyalkyl, C1-C6alkoxy, C2-C6alkyl ether, mono- or di-(C1-C6alkyl)aminoC0-C4alkyl mono- or di-(C1-C6alkyl)aminocarbonyl, C1-C6alkylsulfonyl, C1-C6alkylsulfonylamino, 4- to 7-membered heterocycloalkyl that is optionally substituted with one or two methyl groups, and 5- or 6-membered heteroaryl;
• or
• (ii) taken together to form a 5- to 7-membered heterocycloalkyl that is substituted with from 0 to 4 substituents independently chosen from halogen, hydroxy, cyano, amino, aminocarbonyl, aminosulfonyl, COOH, oxo, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6haloalkyl, C1-C6hydroxyalkyl, C3-C6alkoxy, C1-C6haloalkoxy, C2-C6alkyl ether, (C3-C7cycloalkyl)C0-C4alkyl, mono- or di-(C1-C6alkyl)aminoC0-C4alkyl, mono- or di-(C1-C6alkyl)aminocarbonyl, C1-C6alkylsulfonyl, C1-C6alkylsulfonylamino, 4- to 7-membered heterocycloalkyl that is optionally substituted with one or two methyl groups, and 5- or 6-membered heteroaryl.