US 2013/0172431 A1 · DIAGNOSTIC TEST

Abstract

Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.

Claims21

Dependent claims

A method for treating an inflammatory bowel disease in a human comprising the steps of:

a) obtaining a sample from a patient suspected of having an inflammatory bowel disease and performing an assay to measure a level of soluble TNF receptor II (sTNFRII) in said sample;
b) performing an assay to measure in said sample or another sample obtained from said patient a level of an additional analyte, wherein said additional analyte is MIP-1(3;
and
c) administering a suitable drug to said human if said sTNFRII level is above a predetermined level and said additional analyte level is below a predetermined level.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

13/775,952Filed 25 Feb 2013

Priority

9 Dec 2004

Published

4 Jul 2013

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

G01N 33/6893
Involving proteins, peptides or amino acids: related to diseases not provided for elsewhere
G01N 33/6863
Involving proteins, peptides or amino acids: cytokines, i.e. immune system proteins modifying a biological response such as cell growth…
G01N 2333/523
Chemokines: beta-chemokines, e.g. rantes, i-309/tca-3, mip-1alpha, mip-1beta/act-2/ld78/scif, mcp-1/mcaf, mcp-2, mcp-3, ldcf-1or ldcf-2
G01N 2333/525
Assays involving cytokines: tumor necrosis factor [TNF]

Family

Application60/634,590Us provisional application · filed 9 Dec 2004

Application11/301,274Continuation · filed 9 Dec 2005

Application12/818,093Division · filed 17 Jun 2010

Application13/775,952Division

Application12/818,093Continuation

US 2006/0205012 A1Published application

US 2010/0316992 A1Published application

US 2013/0172431 A1This patent

From the US filing history. Foreign family members aren’t listed.

Diagnostic test

Life of this patent

Diagnostic test

Life of this patent

Abstract

Claims21