Medicaments Based on Dinuclear Arene Ruthenium Complexes Comprising Bridging Thiolato, Selenolato or Alkoxo Ligands
AssigneeUniversite de Neuchatel
InventorsGeorg Suss-Fink, Bruno Therrien, Michael Gras, Paul Joseph Dyson, Olivier Zava, Anne-Flore Ibao
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Abstract
The present invention provides new complexes and medicaments based on dinuclear ruthenium complexes comprising bridging thiolato or selenolato ligands. The complexes comprise a Ru2X3 or a Ru2X2 core, in which each one of said X is independently selected from said bridging ligands, with the proviso that at least one ligand comprises a substituted or unsubstituted phenyl moiety.
Claims23
1-23. (canceled)
24:
- A method of treating a hyperproliferative disorder in an individual in need of such treatment, the method comprising the step of administrating to the individual a complex comprising a structure of any one selected from formula (IIa) and formula (IIb):
- wherein M1 and M2 are a Ru(II) metal atoms;
- wherein R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, and R18 are independently selected from H and from C1-C20 hydrocarbons optionally comprising 0-15 heteroatoms, halogens, hydroxyl, carboxylic acid group, carbonyl, nitro and amino;
- wherein X1, X2, and X3 are, independently, selected from S, Se, and O;
- Z1 and Z2 are independently selected from halogen;
- wherein R1, R3, and R5, in as far as present, are selected, independently, from H, and from C1-C30 hydrocarbons optionally comprising 0-20 heteroatoms, said hydrocarbons being selected from:
- substituted or unsubstituted aryls;
- substituted or unsubstituted aliphatic substituents;
- and
- substituents derived independently from a natural compound and/or a bioactive compound;
- wherein substituents of said aryl and aliphatic substituent, if present, may be selected independently from C1-C20 hydrocarbons comprising 0-15 heteroatoms, halogens, hydroxy, carboxylic acid group, nitro and amino, and wherein two substituents provided on different carbons of said aryl or aliphatic substituent may be connected so as to form one or more ring fused to said aryl or aliphatic substituent.
The method of claim 24,
- wherein X1, X2 and X3 are selected from S and Se;
- wherein substituents R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, and R18 are selected, independently, from:
- C4-C20 hydrocarbons optionally comprising 0-15 heteroatoms, with the proviso that said C4-C20 hydrocarbon optionally comprising 0-15 heteroatoms comprises at least one aromatic ring or ring system and/or comprises at least one bioactive moiety, and further from:
- H, halogens, hydroxyl, carboxylic acid group, nitro and amino, C1-C10 alkyls, C2-C10 alkenyls, C2-C10 alkynyls, C4-C10 aryl, C1-C10 alkoxyl, C2-C10 alkenoxyl, C2-C10 alkynoxyl, C4-C10 aryloxyl, wherein said alkyl, alkoxyl, alkenyl, alkenoxyl, alkynyl, alkynoxyl, may be totally or partially halogenated and may be linear or branched, wherein said aryl and/or an aryl moiety of said aryloxyl, if it is a C4 or a C5 aryl and/or aryloxyl, respectively, it comprises at least on heteroatom, wherein said aryl and aryloxyl may be further substituted, besides with halogen, with C1-C4 alkyl, and wherein substituents on neighbouring carbons of any one or both of the benzene rings in formula (IIa) or (IIb) may be linked so as to form one or more rings fused to said benzene ring.
The method of claim 24, wherein X1, X2 and X3 are S.
The method of claim 24, wherein, in said R1, R3, and R5, in as far as present,
- said aryl is a substituted or unsubstituted phenyl;
- said aliphatic substituent is selected from C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, wherein said alkyl, alkenyl and alkynyl may be substituted and may be linear and, if it comprises at least three carbons, also branched and/or cyclic and, wherein, in said alkyl, alkenyl ad alkynyl, one or more carbons may be replaced by heteroatoms;
- wherein substituents of said phenyl, alkyl, alkenyl, and alkynyl, if present, may be independently selected from halogen, —OH, —COOH, C1-C20 hydrocarbons optionally comprising 0-15 heteroatoms.
The method of claim 24, wherein, if any one of said substituents R1, R3, and R5 is derived from a natural compound and/or bioactive compound, said compound comprises at least one ligand group selected from HS—, HSe—, HO—, or wherein said natural or bioactive compound is covalently connected to a linker moiety comprising one of the aforementioned ligand groups, the linker moiety comprising, said ligand group included, 1-10 carbons and 1-5 heteroatoms, and wherein, in said substituent derived from a natural compound and/or a bioactive compound, the sulphur, selenium, or oxygen group of said HS—, HSe—, or HO— group, respectively, constitutes one or more of X1, X2, and X3 in the complex.
The method of claim 24, wherein R1, R3, and R5, in as far as present, are selected from substituted or unsubstituted C6-C12 aryls, (in particular phenyl and naphthyl) and C1-C10 linear, branched or cyclic alkyls, wherein said aryls and alkyls may be further substituted.
The method of claim 24, wherein said complex comprises a structure of formula (IVa) or (IVb):
- wherein:
- R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, and R18 are selected, independently, from:
- C4-C20 hydrocarbons optionally comprising 0-15 heteroatoms, with the proviso that said C4-C20 hydrocarbon optionally comprising 0-15 heteroatoms comprises at least one aromatic ring or ring system and/or comprises at least one bioactive moiety, and further from:
- H, halogens, hydroxyl, carboxylic acid group, nitro and amino, C1-C10 alkyls, C2-C10 alkenyls, C2-C10 alkynyls, C4-C10 aryl, C1-C10 alkoxyl, C2-C10 alkenoxyl, C2-C10 alkynoxyl, C4-C10 aryloxyl, wherein said alkyl, alkoxyl, alkenyl, alkenoxyl, alkynyl, alkynoxyl, may be totally or partially halogenated and may be linear or branched, wherein said aryl and/or an aryl moiety of said aryloxyl, if it is a C4 or a C5 aryl and/or aryloxyl, respectively, it comprises at least on heteroatom, wherein said aryl and aryloxyl may be further substituted, besides with halogen, with C1-C4 alkyl, and wherein substituents on neighbouring carbons of any one or both of the benzene rings in formula (IIa) or (IIb) may be linked so as to form one or more rings fused to said benzene ring;
- R20, R21, R22 R23, R24, R25, R26, R27, R28, in as far as present, are independently selected from H, halogen, —R30, —O—R30, —O—R35, wherein:
- R30 is independently selected from C1-C8 alkyls, C2-C8 alkenyls, and C2-C8 alkynyls, which, independently, may be linear, and if comprising more than three carbons, branched or cyclic, and which may be totally or partially halogenated, and from substituents of formula (V) below:
- and,
- R35 is derived from a C3-C20 hydrocarbon compound comprising 1 to 15 heteroatoms, said compound being selected from natural compounds and bioactive compounds comprising at least one carboxylic acid group forming, in said substituent R35, an ester bond with the oxygen atom of said —O—R35 substituent;
- wherein R31, R32, R33 are, independently, selected from:
- H;
- halogen;
- C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, which may linear or, if comprising three or more carbons, branched and cyclic, wherein said alkyls, alkenyls and alkynyl may be totally or partially halogenated;
- and,
- substituents —O—R35.
The method of claim 24, wherein:
- R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, and R18 are independently selected from:
- H, halogens, hydroxyl, carboxylic acid group, nitro and amino, C1-C8 alkyls, C2-C8 alkenyls, C2-C8 alkynyls, C4-C8 aryl, C1-C8 alkoxyl, C2-C8 alkenoxyl, C2-C8 alkynoxyl, C4-C10 aryloxyl, all of which may be totally or partially halogenated and wherein said alkyl, alkoxyl, alkenyl, alkenoxyl, alkynyl, alkynoxyl, and aryloxyl may be linear or branched, wherein, if said aryl and/or an aryl moiety of said aryloxyl, if it is a C4 or a C5 aryl and/or aryloxyl, respectively, it comprises at least on heteroatom, and wherein substituents on neighbouring carbons of a given benzene ring in the structure of formulae (IIa), (IIb), (IVa) or (IVb), as applicable, which benzene ring carries R7—R12 or R13—R18, respectively, may be connected so as to form one or more rings fused to said benzene ring.
The method of claim 24, wherein at least one of R7, R8, R9, R10, R11, and R12 is H and/or at least one of R13, R14, R15, R16, R17, and R18, is H.
The method of claim 24, wherein at least one of R7, R8, R9, R10, R11, and R12 is a C3-C4 alkyl and/or at least one of R13, R14, R15, R16, R17, and R18, is a C3-4 alkyl.
The method of claim 24, wherein R7, R8, R9, R10, R11, and R12, are not all alkyl and/or wherein R13, R14, R15, R16, R17, and R18, are not all alkyl.
The method of claim 24, wherein R7, R8, R9, R10, R11, and R12, are not all methyl, and/or wherein R13, R14, R15, R16, R17, and R18, are not all methyl.
The method of claim 24, wherein at least one of R7, R8, R9, R10, R11, and R12, is H and at least one is alkyl;
- and/or wherein at least one of R13, R14, R15, R16, R17, and R18, is H and at least one is alkyl.
The method of claim 24, wherein R7, R8, R9, R10, R11, and R12, are all H, or one is isopropyl and one is methyl, the other substituents being H;
- and/or wherein R13, R14, R15, R16, R17, and R18, are independently selected such that are all H, or one is isopropyl and one is methyl.
The method of claim 24, wherein R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, and R18 are independently selected from:
- H, C1-C5 alkyls, C2-C5 alkenyls, and C2-C5 alkynyls, wherein said alkyl, alkenyl and alkynyl may be linear or branched, and from:
- —(CH2)n—O—C(O)—C6H4p-O—(CH2)mCH3,
- —(CH2)n—O—C(O)—CH═CH—C6H4-p-O—CH3,
- wherein m is, independently, an integer of 1-6 and n being, independently, 1, 2, 3 or 4.
The method of claim 24, wherein said complex is [(arene)2Ru2(SR)3]+ or [(arene)2Ru2(SR)2Z2], wherein:
- arene is selected from C6H6(benzene), C6H5Me (methylbenzene), p-iPrC6H4Me (p-cymene), C9H10 (indane), C6H6—(CH2)n—O—C(O)—C6H4-p-O—(CH2)mCH3, C6H6—(CH2)n—O—C(O)—CH═CH—C6H4-p-O—CH3, with m being an integer of 1-6 and n being 1, 2, 3 or 4;
- and,
- R is selected from phenyl and C1-C3 alkylphenyl, in particular p-C1-C3 alkylphenyl;
- and Z, if present, is selected from Cl, Br, and I.
The method of claim 24, wherein said complex is selected from the group consisting of:
- [(C6H6)2Ru2(SPh)3]+,
- [(C6H6)2Ru2(S-p-C6H4Me)3]+,
- [(C6H5Me)2Ru2(S—Ph)3]+,
- [(C6H5Me)2Ru2(S-p-C6H4Me)3]+,
- [(p-iPrC6H4Me)2Ru2(SPh)3]+,
- [(p-iPrC6H4Me)2Ru2(S-p-C6H4Me)3]+,
- [(C6H6—(CH2)2—O—C(O)—C6H4-p-O—(CH2)6CH3)2Ru2(SPh)3]+,
- [(C6H6—(CH2)2—O—C(O)—C6H4-p-O—(CH2)6CH3)2Ru2(S-p-C6H4Me)3]+,
- [(C6H6—(CH2)4—O—C(O)—C6H4-p-O—(CH2)6CH3)2Ru2(SPh)3]+,
- [(C6H6—(CH2)4—O—C(O)—C6H4-p-O—(CH2)6CH3)2Ru2(S-p-C6H4Me)3]+,
- [trans-(C6H6—(CH2)2—O—C(O)—CH═CH—C6H4-p-O—CH3)2Ru2(SPh)3]+,
- [trans-(C6H6—(CH2)2—O—C(O)—CH═CH—C6H4-p-O—CH3)2Ru2(S-p-C6H4Me)3]+,
- [trans-(C6H6—(CH2)4—O—C(O)—CH═CH—C6H4-p-O—CH3)2Ru2(SPh)3]+,
- [trans-(C6H6—(CH2)4—O—C(O)—CH═CH—C6H4-p-O—CH3)2Ru2(S-p-C6H4Me)3]+,
- [(C6H6)2Ru2(SPh)2Z2],
- [(C6H6)2Ru2(S-p-C6H4Me)2Z2],
- [(C6H5Me)2Ru2(S—Ph)2Z2],
- [(C6H5Me)2Ru2(S-p-C6H4Me)2Z2],
- [(p-iPrC6H4Me)2Ru2(SPh)2Z2], and
- [(p-iPrC6H4Me)2Ru2(S-p-C6H4Me)2 Z2], wherein Z is halogen, preferably Cl.
The method of claim 24, wherein said hyperproliferative disorder is cancer.
Dependencies are inferred from the claim text.