Compositions and methods for silencing smad4
AssigneeProtiva Biotherapeutics, Inc.
InventorsAmmen P. Dhillon, Amy C.H. Lee, Ian MacLachlan
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Abstract
The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA (e.g., dsRNA such as siRNA) that target SMAD4 gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for treating anemia of inflammation in humans).
Claims45
A composition comprising an interfering RNA that silences SMAD4 gene expression, wherein the interfering RNA comprises a sense strand and a complementary antisense strand, and wherein the interfering RNA comprises a double-stranded region of about 15 to about 60 nucleotides in length.
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Dependencies are inferred from the claim text.