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US 2013/0172404 A1Published application
Delivery of Oligonucleotide Functionalized Nanoparticles
AssigneeNorthwestern University
InventorsChad A. Mirkin, Amy S. Paller, David A. Giljohann
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Abstract
The present invention relates to compositions and methods for delivering an oligonucleotide-functionalized nanoparticle.
Claims25
A method of dermal delivery of an oligonucleotide-functionalized nanoparticle comprising the step of:
- administering a therapeutically effective amount of a composition comprising the oligonucleotide-functionalized nanoparticle and a dermal vehicle to the skin of a patient in need thereof.
A method of regulating gene expression comprising the step of:
- administering a therapeutically effective amount of a composition comprising an oligonucleotide-functionalized nanoparticle to skin under conditions wherein the oligonucleotide-functionalized nanoparticle hybridizes to a target and regulates expression of a target polypeptide.
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Dependencies are inferred from the claim text.