Use of derivatives of pentaphyrine as antimicrobial and disinfectant agents
AssigneeUniversità degli Studi di Udine
InventorsRosalisa Fedele, Clara Comuzzi, Giada Rossi, Daniele Goi
Life of this patent
Estimating the term…
Abstract
The invention relates to the use of 20-(4-carboxyphenyl)-2,13-dimethyl-3,12-diethyl-[22] pentaphyrine as antibacterial agent in photodynamic treatment. This expanded porphyrin derivatized in position 4 with a carboxyphenyl group proved very active after photo-oxidation both against S. aureus and E. hirae. Its high antibacterial activity and its low toxicity make this pentaphyrine particularly useful as antimicrobial agent both for photodynamic therapy against bacterial infections and in the disinfection of microbiologically contaminated liquids.
Claims9
A derivative of pentaphyrine consisting of 20-(4-carboxyphenyl)-2,13-dimethyl-3,12-diethyl-[22] pentaphyrine, its metallated derivatives and salts thereof having an antimicrobial activity by photodynamic activation.
A derivative of pentaphyrine selected from the group consisting of 20-(4-carboxyphenyl)-2,13-dimethyl-3,12-diethyl-[22] pentaphyrine, its metallated derivatives and salts thereof for use as photodynamically-activated antimicrobial agent In photodynamic treatment.
A method of treatment of microbial infections by photodynamic therapy comprising the administration in a subject in a need thereof of an effective amount of at least one derivative of pentaphyrine selected from the group consisting of 20-(4-carboxyphenyl)-2,13-dimethyl-3,12-diethyl-[22] pentaphyrine, its metallated derivatives and salts thereof.
A method of disinfection comprising the treatment with an effective amount of at least one derivative of pentaphyrine selected from the group consisting of 20-(4-carboxyphenyl)-2,13-dimethyl-3,12-diethyl-[22] pentaphyrine, its metallated derivatives and salts thereof of, a microbiologically contaminated liquid.
A composition position comprising at least one derivative of pentaphyrine selected from the group consisting of 20-(4-carboxyphenyl)-2,13-dimethyl-3,12-diethyl-[22] pentaphyrine, its metallated derivatives and salts thereof in combination with suitable excipients and/or diluents and/or other active principles for use as antimicrobial and disinfectant agent in photodynamic treatment.
Dependencies are inferred from the claim text.