Use of pramipexole to treat amyotrophic lateral sclerosis
AssigneeUniversity of Virginia Patent Foundation
InventorJames P. Bennett, JR.
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Abstract
The present invention is directed to compositions comprising pramipexole and the use of such compositions to treat neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). As shown in FIG. 6B the mean+/−SEM serum 2,3-DHBA levels for the 12 ALS participants decreased significantly after pramipexole treatment.
Claims10
A method of treating ALS patients, said method comprising the step of administering to said patient a composition comprising a tetrahydrobenthiazole having the general structure:
- wherein R1, R2, R3, and R4, are independently selected from the group consisting of H and C1-C3 alkyl.
A method for enhancing the bioelectric potential ( )Θ) across mitochondrial membranes of cells with impaired mitochondrial energy production, said method comprising the step of contacting said cells with a composition comprising a tetrahydrobenthiazole having the general structure
- wherein R1, R2, R3, and R4, are independently selected from the group consisting of H and C1-C3 alkyl.
A method of reducing oxidative stress in an ALS patient, said method comprising the step of administering to said patient a composition comprising a tetrahydrobenthiazole
- having the general structure:
- wherein R1, R2, and R3 are H and R4 is C1-C3 alkyl.
Dependencies are inferred from the claim text.