Method and composition for prolonging analgesic effect of local anesthetic
AssigneeMackay Memorial Hospital
InventorYu-Chun HUNG
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Abstract
Disclosed herein is a method for prolonging analgesic effect of a membrane permeable local anesthetic in a subject in need thereof. The method uses cinnamaldehyde as an adjuvant which, when administered prior to or simultaneously with the administration of a local anesthetic, prolongs the analgesic effect of the local anesthetic. Also disclosed herein is a method for providing analgesic effect in a subject in need thereof. The method uses cinnamaldehyde as an analgesic compound which, when administered alone to the subject in an analgesically effective amount, provides the analgesic effect.
Claims20
A method for prolonging analgesic effect of a membrane permeable local anesthetic in a subject in need thereof, comprising administering to the subject an anesthetically effective amount of the membrane permeable local anesthetic and an effective amount of cinnamaldehyde for prolonging the analgesic effect of the membrane permeable local anesthetic in the subject, in the absence of a membrane impermeable compound that inhibits one or more voltage-gated ion channels when applied to the internal face of said channels but does not substantially inhibit said channels when applied to the external face of said channels.
A composition for prolonging analgesic effect of a membrane permeable local anesthetic in a subject in need thereof, comprising, an anesthetically effective amount of the membrane permeable local anesthetic or a pharmaceutically acceptable salt thereof;
- an effective amount of cinnamaldehyde or a pharmaceutically acceptable salt thereof for prolonging the analgesic effect of the membrane permeable local anesthetic in the subject;
- and
- a pharmaceutically acceptable excipient;
- wherein the composition is characterized in not having a membrane impermeable compound or a pharmaceutically acceptable salt thereof that inhibits one or more voltage-gated ion channels when applied to the internal face of said channels but does not substantially inhibit said channels when applied to the external face of said channels.
A method for providing analgesic effect in a subject in need thereof, comprising administering to the subject an analgesically effective amount of a cinnamaldehyde.
Dependencies are inferred from the claim text.