Treatment of fibrosing disorders
AssigneeNovartis AG
InventorRuey-Shiuan TSAI
Life of this patent
Estimating the term…
Abstract
A method for treating liver-associated fibrosing disorders or lupus, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula optionally in conjunction with a co-agent.
Claims14
A method for treating liver-associated fibrosing disorders or lupus, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of a compound of formula
- wherein
- R1 is CH3 or C3-6alkynyl,
- R2 is H, —CH2-CH2-OH, —CH2-CH2-O-CH2-CH3,
- X is ═O, (H, H) or (H, OH),
- provided that R2 is other than H when X is ═O and R1 is CH3.
A method for inhibiting epithelial to mesenchymal transition, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I.
A method for reduction of expression of profibrotic growth factors, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I.
A method for reduction of extracellular matrix production, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I.
-15. (canceled)
Dependencies are inferred from the claim text.