Oral dosage forms for oxygen-containing active agents and oxyl-containing polymer

A pharmaceutical matrix tablet for oral administration once every 12 hours, comprising:

• a first active agent that is a tri-oxy active agent,
• a second active agent, and
• a release rate controlling non-ionic oxyl-containing hydrophilic polymer,
• wherein when placed in a USP Type 2 dissolution apparatus at 50 rpm in 900 mL of 0.1 N hydrochloric acid solution in water at 37° C., about 50 wt % of the first active agent is released in about 1.5 hours to about 3.2 hours,
• wherein the ratio of the amount of first active released to the amount of second active agent released at 1 hour and at 4 hours is between about 0.7:1 and about 1.3:1, and wherein the total oxyl content of the hydrophilic polymer is 4×10−4 to about 2×10−3 moles per tablet.

A pharmaceutical matrix tablet for oral administration once every 12 hours, comprising:

• a first active agent that is a tri-oxy active agent,
• a second active agent, and
• a release rate controlling non-ionic oxyl-containing hydrophilic polymer, wherein, the tablet is substantially free of ionic polymer;
• and
• wherein a single-dose administration of one or more tablets to a subject under fed conditions provides a mean Cmax for each of the first active agent and the second active agent that is 70% to 135% of a respective mean Cmax provided by administering the same dosage form to a subject under fasted conditions every 12 hour time period, wherein cumulative dosage amounts administered over the 12 hour time period of each active agent in the dosage form is equivalent to the respective amount of each active agent in the pharmaceutical tablet.